BiomedicalPublications

What veterinary is citing right now

The 40 most-cited open-access veterinary papers published since 2023. Every one is free to read, and each links to the journal that published it — so you can see what that venue costs to publish in while you are there.

Ranked by citations recorded in OpenAlex. The leading paper here has 357. Citation counts favour older papers, so treat this as what the field is building on, not what is newest.

New approach methodologies in human regulatory toxicology – Not if, but how and when!

Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen�, Elisabet Berggren and 25 more · 2023

The predominantly animal-centric approach of chemical safety assessment has increasingly come under pressure. Society is questioning overall performance, sustainability, continued relevance for human health risk assessment and ethics of this system, demanding a change of paradigm. At the same time, the scientific toolbox used for risk assessment is continuously enriched by the development of "New Approach Methodologies" (NAMs). While this term does not define the age or the state of readiness of the innovation, it covers a wide range of methods, including quantitative structure-activity relati…

Environment International357 citationsDOI

Global Estimate of Human Brucellosis Incidence

Christopher G. Laine, Valen E. Johnson, H.M. Scott, Ángela M. Arenas-Gamboa · 2023

Brucellosis is a major public health concern worldwide, especially for persons living in resource-limited settings. Historically, an evidence-based estimate of the global annual incidence of human cases has been elusive. We used international public health data to fill this information gap through application of risk metrics to worldwide and regional at-risk populations. We performed estimations using 3 statistical models (weighted average interpolation, bootstrap resampling, and Bayesian inference) and considered missing information. An evidence-based conservative estimate of the annual globa…

Emerging infectious diseases332 citationsDOI

Brucellosis: epidemiology, pathogenesis, diagnosis and treatment–a comprehensive review

Kamal A. Qureshi, Adil Parvez, Nada A. Fahmy, Bassant H. Abdel Hady and 7 more · 2023

Background: Brucellosis is a pervasive zoonotic disease caused by various Brucella species. It mainly affects livestock and wildlife and poses significant public health threats, especially in regions with suboptimal hygiene, food safety, and veterinary care standards. Human contractions occur by consuming contaminated animal products or interacting with infected animals. Objective: This study aims to provide an updated understanding of brucellosis, from its epidemiology and pathogenesis to diagnosis and treatment strategies. It emphasizes the importance of ongoing research, knowledge exchange,…

Annals of Medicine297 citationsDOI

The Importance of Animal Models in Biomedical Research: Current Insights and Applications

Adriana Domínguez-Oliva, Ismael Hernández-Ávalos, Julio Martı́nez-Burnes, Adriana Olmos-Hernández and 2 more · 2023

Animal research is considered a key element in advance of biomedical science. Although its use is controversial and raises ethical challenges, the contribution of animal models in medicine is essential for understanding the physiopathology and novel treatment alternatives for several animal and human diseases. Current pandemics' pathology, such as the 2019 Coronavirus disease, has been studied in primate, rodent, and porcine models to recognize infection routes and develop therapeutic protocols. Worldwide issues such as diabetes, obesity, neurological disorders, pain, rehabilitation medicine,…

Animals258 citationsDOI

Guidance on the planning and reporting of experimental design and analysis

Michael J. Curtis, S P H Alexander, Miriam M. Cortese‐Krott, David A. Kendall and 13 more · 2025

The aim of this guidance document is to help authors plan experiments, conduct analyses and present the results of work intended for publication in the British Journal of Pharmacology (BJP). The guidance is structured to minimize the risk of generating and publishing false findings. Below, we explain the key elements of experimental planning (blinding, randomization and adequate group sizes) and how to avoid generating incorrect findings (false positives in particular). We explain how to capture the relevant design and analysis information in your manuscript so it can be examined quickly, effi…

British Journal of Pharmacology241 citationsDOI

World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guideline for diagnosing anthelmintic resistance using the faecal egg count reduction test in ruminants, horses and swine

Ray M. Kaplan, Matthew Denwood, Martin K. Nielsen, Stig Milan Thamsborg and 5 more · 2023

The faecal egg count reduction test (FECRT) remains the method of choice for establishing the efficacy of anthelmintic compounds in the field, including the diagnosis of anthelmintic resistance. We present a guideline for improving the standardization and performance of the FECRT that has four sections. In the first section, we address the major issues relevant to experimental design, choice of faecal egg count (FEC) method, statistical analysis, and interpretation of the FECRT results. In the second section, we make a series of general recommendations that are applicable across all animals ad…

Veterinary Parasitology224 citationsDOI

New approach methodologies (NAMs): identifying and overcoming hurdles to accelerated adoption

Fiona Sewell, Camilla Alexander‐White, Susy Brescia, A Currie and 5 more · 2024

Abstract New approach methodologies (NAMs) can deliver improved chemical safety assessment through the provision of more protective and/or relevant models that have a reduced reliance on animals. Despite the widely acknowledged benefits offered by NAMs, there continue to be barriers that prevent or limit their application for decision-making in chemical safety assessment. These include barriers related to real and perceived scientific, technical, legislative and economic issues, as well as cultural and societal obstacles that may relate to inertia, familiarity, and comfort with established met…

Toxicology Research186 citationsDOI

The Economic Impact of Parasitism from Nematodes, Trematodes and Ticks on Beef Cattle Production

Tom Strydom, Robert P. Lavan, Siddhartha Torres, Kathleen Heaney · 2023

Global human population growth requires the consumption of more meat such as beef to meet human needs for protein intake. Cattle parasites are a constant and serious threat to the development of the beef cattle industry. Studies have shown that parasites not only reduce the performance of beef cattle, but also negatively affect the profitability of beef agriculture and have many other impacts, including contributing to the production of greenhouse gases. In addition, some zoonotic parasitic diseases may also threaten human health. Therefore, ongoing cattle parasite research is crucial for cont…

Animals167 citationsDOI

Toxic or not toxic? The specifications of the standard ISO 10993-5 are not explicit enough to yield comparable results in the cytotoxicity assessment of an identical medical device

Sarah Gruber, Angela Nickel · 2023

Background: cytotoxicity tests. This test evaluates the effects of medical device use on cell health. The existence of the specific standard suggests that the tests will produce reliable and comparable results. However, the ISO 10993-5 offers wide latitude in the test specifications. In the past, we noticed inconsistencies of the results from different laboratories. Objective: To determine if the specifications of the standard ISO 10993-5 are explicit to ensure the comparability of test results and, if not, identify potential influencing factors. Methods: cytotoxicity test according to ISO 109…

Frontiers in Medical Technology167 citationsDOI

Precision Livestock Farming Technology: Applications and Challenges of Animal Welfare and Climate Change

G. Papakonstantinou, Nikolaos Voulgarakis, Georgia Terzidou, Lampros Fotos and 2 more · 2024

This study aimed to review recent developments in the agri-food industry, focusing on the integration of innovative digital systems into the livestock industry. Over the last 50 years, the production of animal-based foods has increased significantly due to the rising demand for meat. As a result, farms have increased their livestock numbers to meet consumer demand, which has exacerbated challenges related to environmental sustainability, human health, and animal welfare. In response to these challenges, precision livestock farming (PLF) technologies have emerged as a promising solution for sus…

Agriculture136 citationsDOI

Artificial Intelligence and Sensor Innovations: Enhancing Livestock Welfare with a Human-Centric Approach

Suresh Neethirajan · 2023

Abstract In the wake of rapid advancements in artificial intelligence (AI) and sensor technologies, a new horizon of possibilities has emerged across diverse sectors. Livestock farming, a domain often sidelined in conventional AI discussions, stands at the cusp of this transformative wave. This paper delves into the profound potential of AI and sensor innovations in reshaping animal welfare in livestock farming, with a pronounced emphasis on a human-centric paradigm. Central to our discourse is the symbiotic interplay between cutting-edge technology and human expertise. While AI and sensor mec…

Human-Centric Intelligent Systems129 citationsDOI

Research progress on complications of Brucellosis

Jin Min, Zixu Fan, Ruifang Gao, Xingnan Li and 2 more · 2023

B rucellosis is a common zoonotic disease that is widely spread worldwide and poses a major threat to human health. Clinically, it often presents with non-specific symptoms such as fever, excessive sweating, malaise, myalgia, arthralgia, loss of appetite, weight loss, and enlarged liver, spleen and lymph nodes. The disease has a long and recurrent course, often accumulating in multiple systems and organs. Of these, osteoarticular involvement is the most common complication, with a prevalence of approximately 2-77%, usually manifesting as spondylitis, sacroiliac arthritis and peripheral arthrit…

Frontiers in Cellular and Infection Microbiology129 citationsDOI

An Overlooked and Underrated Endemic Mycosis—Talaromycosis and the Pathogenic Fungus Talaromyces marneffei

Fang Wang, Runhua Han, Shi Chen · 2023

growth biology are discussed in this review, along with the interaction of the fungus with environmental stimuli and the host immune response to fungal infection. Importantly, the future research directions required for understanding this serious infection and its causative pathogenic fungus are also emphasized to identify solutions that will alleviate the suffering of susceptible individuals worldwide.…

Clinical Microbiology Reviews127 citationsDOI

Long ignored but making a comeback: a worldwide epidemiological evolution of human brucellosis

Zhiguo Liu, Liping Gao, Miao Wang, Min Yuan and 1 more · 2023

Brucellosis is a commonly neglected zoonosis that remains a serious global public health concern. The epidemiological evolution of human brucellosis has considerably changed over the past few decades, and epidemic geography is continuously expanding. Human brucellosis is emerging and re-emerging, and is imported from areas where it is endemic due to travel, immigration, and international trade. The disease continues to be prevalent in Asia and Africa, including West Asia, Central Asia, North Africa, and East Africa, with the highest incidence in Syria, Kyrgyzstan, Mongolia, Iran, Algeria, and…

Emerging Microbes & Infections122 citationsDOI

A consensus on the definition of positive animal welfare

Jean‐Loup Rault, Melissa Bateson, Alain Boissy, Björn Forkman and 16 more · 2025

The concept of animal welfare is evolving due to progress in our scientific understanding of animal biology and changing societal expectations. Animal welfare science has been primarily concerned with minimizing suffering, but there is growing interest in also promoting positive experiences, grouped under the term positive animal welfare (PAW). However, there are discrepancies in the use of the term PAW. An interdisciplinary group arrived at a consensus that 'PAW can be defined as the animal flourishing through the experience of predominantly positive mental states and the development of compe…

Biology Letters120 citationsDOI

Mouse and Rat Anesthesia and Analgesia

Sang Su Oh, Heather L. Narver · 2024

Anesthesia and analgesia play pivotal roles in ethically and humanely using animal models in research, especially concerning mice and rats. These rodent species, extensively utilized in scientific investigations due to their genetic resemblance to humans, serve as invaluable tools for studying diseases and testing treatments. Proper anesthesia and analgesia not only prioritize animal welfare but also heighten experimental validity by minimizing stress-induced physiological responses. Recent years have seen remarkable advancements in anesthesia for mice and rats. The focus has shifted away from…

Current Protocols108 citationsDOI

Precision Livestock Farming Applications (PLF) for Grazing Animals

Christos Tzanidakis, Ouranios Tzamaloukas, Panagiotis Simitzis, P. Panagakis · 2023

Over the past four decades the dietary needs of the global population have been elevated, with increased consumption of animal products predominately due to the advancing economies of South America and Asia. As a result, livestock production systems have expanded in size, with considerable changes to the animals’ management. As grazing animals are commonly grown in herds, economic and labour constraints limit the ability of the producer to individually assess every animal. Precision Livestock Farming refers to the real-time continuous monitoring and control systems using sensors and computer a…

Agriculture108 citationsDOI

Prevalence of lameness in dairy cows: A literature review

Peter T. Thomsen, Jan K. Shearer, Hans Houe · 2023

Lameness in dairy cows has major negative impacts on animal welfare and production economy. While previous studies have evaluated the prevalence of lameness in single countries, the present literature review is the first overview of the prevalence of lameness in dairy cows globally. This literature review identified 53 studies reporting prevalence of lameness among representative samples of dairy cows and fulfilling a number of specified inclusion criteria (e.g., at least 10 herds and 200 cows, and locomotion scoring by trained observers). A total of 414,950 cows from 3945 herds were included…

The Veterinary Journal105 citationsDOI

Xylazine in Overdose Deaths and Forensic Drug Reports in US States, 2019-2022

Manuel Cano, Raminta Daniulaityte, Flavio F. Marsiglia · 2024

Importance: Xylazine is increasingly reported in street drugs and fatal overdoses in the US, yet state-level data are limited, hampering local public health responses. Objective: To gather available state-level data on xylazine involvement in overdose deaths and in forensic drug reports. Design, Setting, and Participants: This cross-sectional study was a secondary analysis of 2019 to 2022 data from the National Forensic Laboratory Information System (NFLIS), National Center for Health Statistics, and individual states' medical examiner or public health agency reports. Data were analyzed from A…

JAMA Network Open98 citationsDOI

Choice, control, and animal welfare: definitions and essential inquiries to advance animal welfare science

Maisy D. Englund, Katherine A. Cronin · 2023

The ways in which humans can support good welfare for animals in their care is an ongoing subject of debate: some place emphasis on the animals' physical health; others, on animals' ability to live "natural lives"; and others on animals' affective states or psychological wellbeing. Recently, there has been an increase in interest in how an animal's ability to exercise control over its environment could impact their welfare. In this article, we take the stance that the relevant aspects of the first two concepts of animal welfare (physical health, natural lives) are largely addressed when an ani…

Frontiers in Veterinary Science96 citationsDOI

Molecular evidence of widespread benzimidazole drug resistance in Ancylostoma caninum from domestic dogs throughout the USA and discovery of a novel β-tubulin benzimidazole resistance mutation

Abhinaya Venkatesan, Pablo D. Jimenez Castro, Arianna Morosetti, Hannah Horvath and 8 more · 2023

Ancylostoma caninum is an important zoonotic gastrointestinal nematode of dogs worldwide and a close relative of human hookworms. We recently reported that racing greyhound dogs in the USA are infected with A. caninum that are commonly resistant to multiple anthelmintics. Benzimidazole resistance in A. caninum in greyhounds was associated with a high frequency of the canonical F167Y(TTC>TAC) isotype-1 β-tubulin mutation. In this work, we show that benzimidazole resistance is remarkably widespread in A. caninum from domestic dogs across the USA. First, we identified and showed the functional si…

PLoS Pathogens95 citationsDOI

The “Big Three” in biocompatibility testing of medical devices: implementation of alternatives to animal experimentation—are we there yet?

Helena Kanďárová, P. Pôbiš · 2024

Biocompatibility testing ensures the safety of medical devices by assessing their compatibility with biological systems and their potential to cause harm or adverse reactions. Thus, it is a critical part of the overall safety evaluation process for medical devices. Three primary types of biocompatibility tests—cytotoxicity, irritation, and sensitisation assessment—are standard for nearly all medical devices. However, additional biocompatibility tests, such as genotoxicity, systemic toxicity, hemocompatibility, and implantation studies, may also be necessary, depending on the device’s nature an…

Frontiers in Toxicology94 citationsDOI

Opioid overdoses involving xylazine in emergency department patients: a multicenter study

Jennifer S. Love, Michael S. Levine, Kim Aldy, Jeffrey Brent and 16 more · 2023

Introduction Illicit opioids, consisting largely of fentanyl, novel synthetic opioids, and adulterants, are the primary cause of drug overdose fatality in the United States. Xylazine, an alpha-2 adrenergic agonist and veterinary tranquilizer, is being increasingly detected among decedents following illicit opioid overdose. Clinical outcomes in non-fatal overdose involving xylazine are unexplored. Therefore, among emergency department patients with illicit opioid overdose, we evaluated clinical outcome differences for patients with and without xylazine exposures.Methods This multicenter, prospe…

Clinical Toxicology92 citationsDOI

Precision Livestock Farming: What Does It Contain and What Are the Perspectives?

J. L. Kleen, Raphaël R. Guatteo · 2023

Precision Livestock Farming (PLF) describes the combined use of sensor technology, the related algorithms, interfaces, and applications in animal husbandry. PLF technology is used in all animal production systems and most extensively described in dairy farming. PLF is developing rapidly and is moving beyond health alarms towards an integrated decision-making system. It includes animal sensor and production data but also external data. Various applications have been proposed or are available commercially, only a part of which has been evaluated scientifically; the actual impact on animal health…

Animals90 citationsDOI

Reducing the harms of xylazine: clinical approaches, research deficits, and public health context

Claire M. Zagorski, Rebecca A. Hosey, Christopher Moraff, Aaron Ferguson and 6 more · 2023

OBJECTIVES: Xylazine has emerged as a consistent part of the unregulated drug supply in recent months. We discuss major domains of xylazine's harm, current knowledge deficits, clinical and harm reduction strategies for minimizing harm, and xylazine's public health and policy context. As an interdisciplinary team from across the USA, we have pooled our knowledge to provide an overview of xylazine's current and emerging contexts. METHODS: To inform this essay, the pertinent literature was reviewed, clinical knowledge and protocols were shared by multiple clinicians with direct expertise, and pol…

Harm Reduction Journal88 citationsDOI

Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications

Benjamin Victor Ineichen, Eva Furrer, Servan Grüninger, Wolfgang Emanuel Zürrer and 1 more · 2024

There is an ongoing debate about the value of animal experiments to inform medical practice, yet there are limited data on how well therapies developed in animal studies translate to humans. We aimed to assess 2 measures of translation across various biomedical fields: (1) The proportion of therapies which transition from animal studies to human application, including involved timeframes; and (2) the consistency between animal and human study results. Thus, we conducted an umbrella review, including English systematic reviews that evaluated the translation of therapies from animals to humans.…

PLoS Biology83 citationsDOI

Practical guide to the diagnostics of ruminant gastrointestinal nematodes, liver fluke and lungworm infection: interpretation and usability of results

Gustavo Adolfo Sabatini, Fernando de Almeida Borges, Edwin Claerebout, Leonor Sicalo Gianechini and 8 more · 2023

The diagnostics of ruminant parasites remains one of the cornerstones for parasite control best practices. Field veterinarians have several techniques at their disposal (fecal egg count, coproculture, FAMACHA®, plasma pepsinogen, ELISA-Ostertagia, ELISA-Fasciola, Baermann and ELISA-Lungworm) for the identification and/or quantification of gastrointestinal nematodes, lungworms and liver fluke infecting small ruminants and cattle. Each of these diagnostic tools has its own strengths and weaknesses and is more appropriate for a specific production operation and/or age of the animal (young and adu…

Parasites & Vectors82 citationsDOI

The (misleading) role of animal models in drug development

Thomas Härtung · 2024

Animals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal models can also mislead drug development. This article explains for a general audience how animal research is used to develop new medicines, its benefits and limitations, and how more accurate and humane techniques—alternatives to animal testing—could improve this process.…

Frontiers in Drug Discovery81 citationsDOI

Advancements in artificial intelligence technology for improving animal welfare: Current applications and research progress

Li Zhang, Wenqiang Guo, Chenrui Lv, Meng Guo and 3 more · 2023

Abstract The integration of Artificial Intelligence (AI) in various sectors has led to significant advancements, with the animal industry being no exception. This review aims to investigate the benefits, limitations, and future prospects of AI technology in improving animal welfare. First, it examines the role of AI in understanding animal behaviors and emotions, providing deeper insights into their well‐being and sources of stress. Next, the paper explores how AI can revolutionize animal nutrition through innovative algorithms and data analytics. The health aspect emphasizes the ability of AI…

Animal Research and One Health80 citationsDOI

Dietary nutrition, intestinal microbiota dysbiosis and post-weaning diarrhea in piglets

Xuebing Han, Xiangdong Hu, Wei Jin, Gang Liu · 2024

Weaning is a critical transitional point in the life cycle of piglets. Early weaning can lead to post-weaning syndrome, destroy the intestinal barrier function and microbiota homeostasis, cause diarrhea and threaten the health of piglets. The nutritional components of milk and solid foods consumed by newborn animals can affect the diversity and structure of their intestinal microbiota, and regulate post-weaning diarrhea in piglets. Therefore, this paper reviews the effects and mechanisms of different nutrients, including protein, dietary fiber, dietary fatty acids and dietary electrolyte balan…

Animal nutrition80 citationsDOI

Stress in wildlife: comparison of the stress response among domestic, captive, and free-ranging animals

Mina Cansu Karaer, Nina Čebulj-Kadunc, Tomaž Snoj · 2023

The stress response, which involves joint activity of the nervous and endocrine systems, is one of the basic adaptive mechanisms that ensures the survival of the individual. The activation of the sympathetic nervous system, the sympathetic-adrenal-medullary axis, and the hypothalamic-pituitary-adrenal axis enables organisms to respond to endogenous and exogenous challenges. Repeated short-term stress leads to long-term stress, which disrupts physiological homeostasis. Unlike domestic animals, wild animals are not protected from environmental and weather influences or treated for diseases. In a…

Frontiers in Veterinary Science79 citationsDOI

Review: Towards an integrated concept of animal welfare

Inonge Reimert, Laura E. Webb, Manon A. van Marwijk, J.E. Bolhuis · 2023

Animal welfare is an important field of study due to animal sentience, yet there is to date no consensus on the definition of animal welfare. There have been four key developments in the field of animal welfare science since its birth: the theoretical and empirical study of affective states, and hence our understanding thereof, has increased; there has been a shift from a primary focus on unpleasant experiences towards an inclusion of pleasant experiences; there has been an increasing mention and investigation of the notion of cumulation of experiences in time, and with this, the importance of…

animal77 citationsDOI

Guidance on the assessment of biocompatibility of biomaterials: Fundamentals and testing considerations

Vinícius Rosa, Nick Silikas, Baiqing Yu, Nileshkumar Dubey and 7 more · 2024

BACKGROUND: Assessing the biocompatibility of materials is crucial for ensuring the safety and well-being of patients by preventing undesirable, toxic, immune, or allergic reactions, and ensuring that materials remain functional over time without triggering adverse reactions. To ensure a comprehensive assessment, planning tests that carefully consider the intended application and potential exposure scenarios for selecting relevant assays, cell types, and testing parameters is essential. Moreover, characterizing the composition and properties of biomaterials allows for a more accurate understan…

Dental Materials76 citationsDOI

Life expectancy tables for dogs and cats derived from clinical data

Mathieu Montoya, Jo Ann Morrison, Florent Arrignon, Nate Spofford and 3 more · 2023

There are few recent and methodologically robust life expectancy (LE) tables for dogs or cats. This study aimed to generate LE tables for these species with clinical records from >1,000 Banfield Pet hospitals in the USA. Using Sullivan's method, LE tables were generated across survey years 2013–2019, by survey year, and for subpopulations defined by sex, adult body size group (purebred dogs only: toy, small, medium, large and giant), and median body condition score (BCS) over life. The deceased population for each survey year comprised animals with a recorded date of death in that year; surviv…

Frontiers in Veterinary Science75 citationsDOI

Equine Gastric Ulcer Syndrome: An Update on Current Knowledge

Jessica Vokes, A Lovett, B. W. Sykes · 2023

Equine Gastric Ulcer Syndrome (EGUS) is a term that has been used since 1999, initially being used to describe all gastric mucosal disease in horses. Since this time, the identification of two distinct main disease entities of the equine gastric mucosa have been described under the umbrella of EGUS; these are Equine Squamous Gastric Disease (ESGD) and Equine Glandular Gastric Disease (EGGD). In 2015 the European College of Equine Internal Medicine (ECEIM) released a consensus statement defining these disease entities. This document highlighted the lack of evidence surrounding EGGD compared to…

Animals72 citationsDOI

The Significance and Ethics of Digital Livestock Farming

Suresh Neethirajan · 2023

The emergence of precision and digital livestock farming presents an opportunity for sustainable animal farming practices that enhance animal welfare and health. However, this transformation of modern animal farming through digital technology has several implications for the technological, social, economic, and environmental aspects of farming. It is crucial to analyze the ethical considerations associated with the digitalization of modern animal farming, particularly in the context of human–animal relationships and potential objectification. This analysis can help develop frameworks for impro…

AgriEngineering71 citationsDOI