BiomedicalPublications

What nursing is citing right now

The 40 most-cited open-access nursing papers published since 2023. Every one is free to read, and each links to the journal that published it — so you can see what that venue costs to publish in while you are there.

Ranked by citations recorded in OpenAlex. The leading paper here has 2,438. Citation counts favour older papers, so treat this as what the field is building on, not what is newest.

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Klaudia Jomová, Renáta Raptová, Suliman Yousef Alomar, Saleh Alwasel and 3 more · 2023

A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or "good stress" and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2-related factor 2 (Nrf2) and other processes. Increased levels of ROS/RNS, gen…

Archives of Toxicology2,438 citationsDOI

Cuproptosis: mechanisms and links with cancers

Jiaming Xie, Yannan Yang, Yibo Gao, Jie He · 2023

Cuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of cell death. The last decade has witnessed a considerable increase in investigations of programmed cell death, and whether copper induced cell death was an independent form of cell death has long been argued until mechanism of cuproptosis has been revealed. After that, increasing number of researchers attempted to identify the relationship between cuproptosis and the process of cancer. Thus, in this review, we systematically detailed the systemic and cellular metabolic processes of co…

Molecular Cancer798 citationsDOI

Copper metabolism in cell death and autophagy

Qian Xue, Rui Kang, Daniel J. Klionsky, Daolin Tang and 2 more · 2023

ACSL4, acyl-CoA synthetase long chain family member 4; AIFM1/AIF, apoptosis inducing factor mitochondria associated 1; AIFM2, apoptosis inducing factor mitochondria associated 2; ALDH, aldehyde dehydrogenase; ALOX, arachidonate lipoxygenase; AMPK, AMP-activated protein kinase; APAF1, apoptotic peptidase activating factor 1; ATF4, activating transcription factor 4; ATG, autophagy related; ATG13, autophagy related 13; ATG5, autophagy related 5; ATOX1, antioxidant 1 copper chaperone; ATP, adenosine triphosphate; ATP7A, ATPase copper transporting alpha; ATP7B, ATPase copper transporting beta; BAK1…

Autophagy670 citationsDOI

Research progress of glutathione peroxidase family (GPX) in redoxidation

Jun Pei, Xingyu Pan, Guanghui Wei, Yi Hua · 2023

Maintaining the balance of a cell’s redox function is key to determining cell fate. In the critical redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent family of proteins with a multifaceted function that affects almost all cellular processes. A total of eight members of the GPX family are currently found, namely GPX1-GPX8. They have long been used as antioxidant enzymes to play an important role in combating oxidative stress and maintaining redox balance. However, each member of the GPX family has a different mechanism of action and site of action in maintainin…

Frontiers in Pharmacology596 citationsDOI

Biological Activity of Selenium and Its Impact on Human Health

Giuseppe Genchi, Graziantonio Lauria, Alessia Catalano, Maria Stefania Sinicropi and 1 more · 2023

Selenium (Se) is a naturally occurring metalloid element essential to human and animal health in trace amounts but it is harmful in excess. Se plays a substantial role in the functioning of the human organism. It is incorporated into selenoproteins, thus supporting antioxidant defense systems. Selenoproteins participate in the metabolism of thyroid hormones, control reproductive functions and exert neuroprotective effects. Among the elements, Se has one of the narrowest ranges between dietary deficiency and toxic levels. Its level of toxicity may depend on chemical form, as inorganic and organ…

International Journal of Molecular Sciences378 citationsDOI

Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets

Zenglei Zhang, Lin Zhao, Xingyu Zhou, Xingyu Zhou and 3 more · 2023

Hypertension is regarded as the most prominent risk factor for cardiovascular diseases, which have become a primary cause of death, and recent research has demonstrated that chronic inflammation is involved in the pathogenesis of hypertension. Both innate and adaptive immunity are now known to promote the elevation of blood pressure by triggering vascular inflammation and microvascular remodeling. For example, as an important part of innate immune system, classically activated macrophages (M1), neutrophils, and dendritic cells contribute to hypertension by secreting inflammatory cy3tokines. In…

Frontiers in Immunology370 citationsDOI

Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

Bonan Chen, Peiyao Yu, Wai Nok Chan, Fuda Xie and 8 more · 2024

Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellular equilibrium, cellular zinc has been increasingly spotlighted in the context of disease development. Extensive research suggests zinc's involvement in promoting malignancy and invasion in cancer cells, despite its low tissue concentration. This has led to a growing body of literature investigating zinc's cellular metabolism, particularly the functions of…

Signal Transduction and Targeted Therapy362 citationsDOI

Selenium and Selenoproteins in Health

Fan Zhang, Xue‐Lian Li, Yumiao Wei · 2023

Selenium is a trace mineral that is essential for health. After being obtained from food and taken up by the liver, selenium performs various physiological functions in the body in the form of selenoproteins, which are best known for their redox activity and anti-inflammatory properties. Selenium stimulates the activation of immune cells and is important for the activation of the immune system. Selenium is also essential for the maintenance of brain function. Selenium supplements can regulate lipid metabolism, cell apoptosis, and autophagy, and have displayed significant alleviating effects in…

Biomolecules350 citationsDOI

Burden of disease attributable to unsafe drinking water, sanitation, and hygiene in domestic settings: a global analysis for selected adverse health outcomes

Jennyfer Wolf, Richard B. Johnston, Argaw Ambelu, Benjamin F. Arnold and 17 more · 2023

BACKGROUND: Assessments of disease burden are important to inform national, regional, and global strategies and to guide investment. We aimed to estimate the drinking water, sanitation, and hygiene (WASH)-attributable burden of disease for diarrhoea, acute respiratory infections, undernutrition, and soil-transmitted helminthiasis, using the WASH service levels used to monitor the UN Sustainable Development Goals (SDGs) as counterfactual minimum risk-exposure levels. METHODS: We assessed the WASH-attributable disease burden of the four health outcomes overall and disaggregated by region, age, a…

The Lancet328 citationsDOI

A druggable copper-signalling pathway that drives inflammation

Stéphanie Solier, Sebastian Müller, Tatiana Cañeque, Antoine Versini and 30 more · 2023

Abstract Inflammation is a complex physiological process triggered in response to harmful stimuli 1 . It involves cells of the immune system capable of clearing sources of injury and damaged tissues. Excessive inflammation can occur as a result of infection and is a hallmark of several diseases 2–4 . The molecular bases underlying inflammatory responses are not fully understood. Here we show that the cell surface glycoprotein CD44, which marks the acquisition of distinct cell phenotypes in the context of development, immunity and cancer progression, mediates the uptake of metals including copp…

Nature324 citationsDOI

Effects of Malnutrition on the Immune System and Infection and the Role of Nutritional Strategies Regarding Improvements in Children’s Health Status: A Literature Review

Fátima Morales, Sergio Montserrat‐de la Paz, María José León, Fernando Rivero‐Pino · 2023

Malnutrition refers to a person's status as under- or overnourished, and it is usually associated with an inflammation status, which can subsequently imply a different health status, as the risk of infection is increased, along with a deterioration of the immune system. Children's immune systems are generally more susceptible to problems than adults. In the situation of malnutrition, because malnourished children's immune systems are compromised, they are more likely to die. However, little is known about the underlying mechanism of altered immune functioning and how it relates to starvation.…

Nutrients313 citationsDOI

Effect of protein–starch interactions on starch retrogradation and implications for food product quality

Gabrielle Scott, Joseph M. Awika · 2023

Starch retrogradation is a consequential part of food processing that greatly impacts the texture and acceptability of products containing both starch and proteins, but the effect of proteins on starch retrogradation has only recently been explored. With the increased popularity of plant-based proteins in recent years, incorporation of proteins into starch-based products is more commonplace. These formulation changes may have unforeseen effects on ingredient functionality and sensory outcomes of starch-containing products during storage, which makes the investigation of protein-starch interact…

Comprehensive Reviews in Food Science and Food Safety305 citationsDOI

The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics

Mengli Zheng, Yating Liu, Guanfeng Zhang, Zhikang Yang and 2 more · 2023

Superoxide dismutase (SOD) is a class of enzymes that restrict the biological oxidant cluster enzyme system in the body, which can effectively respond to cellular oxidative stress, lipid metabolism, inflammation, and oxidation. Published studies have shown that SOD enzymes (SODs) could maintain a dynamic balance between the production and scavenging of biological oxidants in the body and prevent the toxic effects of free radicals, and have been shown to be effective in anti-tumor, anti-radiation, and anti-aging studies. This research summarizes the types, biological functions, and regulatory m…

Antioxidants291 citationsDOI

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

Consuelo Santa‐María, Soledad López, Sergio Montserrat‐de la Paz, Isabel Geniz and 5 more · 2023

In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high nutraceutical value. The positive effects of olive oil have often been attributed to its minor components; however, its oleic acid (OA) content (70-80%) is responsible for its many health properties. OA is an effective biomolecule, although the mechanism by which OA mediates beneficial physiological effects is not fully understood. OA influences cell membrane fluidity, receptors, intracellular signaling pathways, and gen…

Nutrients289 citationsDOI

Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies

Xinyue Chen, Qi Cai, Ruikai Liang, Deju Zhang and 8 more · 2023

Copper is a vital mineral, and an optimal amount of copper is required to support normal physiologic processes in various systems, including the cardiovascular system. Over the past few decades, copper-induced cell death, named cuproptosis, has become increasingly recognized as an important process mediating the pathogenesis and progression of cardiovascular disease (CVD), including atherosclerosis, stroke, ischemia-reperfusion injury, and heart failure. Therefore, an in-depth understanding of the regulatory mechanisms of cuproptosis in CVD may be useful for improving CVD management. Here, we…

Cell Death and Disease279 citationsDOI

Zinc: From Biological Functions to Therapeutic Potential

Maria Inês Costa, Ana Bela Sarmento‐Ribeiro, Ana Cristina Gonçalves · 2023

The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chroni…

International Journal of Molecular Sciences249 citationsDOI

Role of zinc in health and disease

Lucy I. Stiles, Kevin Ferrao, Kosha J. Mehta · 2024

This review provides a concise overview of the cellular and clinical aspects of the role of zinc, an essential micronutrient, in human physiology and discusses zinc-related pathological states. Zinc cannot be stored in significant amounts, so regular dietary intake is essential. ZIP4 and/or ZnT5B transport dietary zinc ions from the duodenum into the enterocyte, ZnT1 transports zinc ions from the enterocyte into the circulation, and ZnT5B (bidirectional zinc transporter) facilitates endogenous zinc secretion into the intestinal lumen. Putative promoters of zinc absorption that increase its bio…

Clinical and Experimental Medicine248 citationsDOI

Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance

Yumin Wang, Yumin Wang, Yongming Chen, Junjing Zhang and 8 more · 2023

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of copper and copper triggered cell death in the pathogenesis of cancers have attracted attentions. Cuproptosis has garnered enormous interest in cancer research communities because of its great potential for cancer therapy. Copper-based treatment exerts an inhibiting role in tumor growth and may open the door for the treatment of chemotherapy-insensitive tumors. In this review, we provide a critical analysis on copper homeostasis and the role of copper dysregulation in the development and progression of…

Drug Resistance Updates248 citationsDOI

The power of magnesium: unlocking the potential for increased yield, quality, and stress tolerance of horticultural crops

Nazir Ahmed, Baige Zhang, Bilquees Bozdar, Sadaruddin Chachar and 6 more · 2023

Magnesium (Mg2+) is pivotal for the vitality, yield, and quality of horticultural crops. Central to plant physiology, Mg2+ powers photosynthesis as an integral component of chlorophyll, bolstering growth and biomass accumulation. Beyond basic growth, it critically affects crop quality factors, from chlorophyll synthesis to taste, texture, and shelf life. However, Mg2 + deficiency can cripple yields and impede plant development. Magnesium Transporters (MGTs) orchestrate Mg2+ dynamics, with notable variations observed in horticultural species such as Cucumis sativus, Citrullus lanatus, and Citru…

Frontiers in Plant Science236 citationsDOI

Functional effects of human milk oligosaccharides (HMOs)

Meltem Dinleyici, Jana Barbieur, Ener Çağrı Dinleyici, Yvan Vandenplas · 2023

Human milk oligosaccharides (HMOs) are the third most important solid component in human milk and act in tandem with other bioactive components. Individual HMO levels and distribution vary greatly between mothers by multiple variables, such as secretor status, race, geographic region, environmental conditions, season, maternal diet, and weight, gestational age and mode of delivery. HMOs improve the gastrointestinal barrier and also promote a bifidobacterium-rich gut microbiome, which protects against infection, strengthens the epithelial barrier, and creates immunomodulatory metabolites. HMOs…

Gut Microbes223 citationsDOI

ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury

Shengqi Huo, Qian Wang, Wei Shi, Lulu Peng and 9 more · 2023

Cuproptosis resulting from copper (Cu) overload has not yet been investigated in diabetic cardiomyopathy (DCM). Advanced glycosylation end products (AGEs) induced by persistent hyperglycemia play an essential role in cardiotoxicity. To clarify whether cuproptosis was involved in AGEs-induced cardiotoxicity, we analyzed the toxicity of AGEs and copper in AC16 cardiomyocytes and in STZ-induced or db/db-diabetic mouse models. The results showed that copper ionophore elesclomol induced cuproptosis in cardiomyocytes. It was only rescued by copper chelator tetrathiomolybdate rather than by other cel…

International Journal of Molecular Sciences220 citationsDOI

Customizing Starch Properties: A Review of Starch Modifications and Their Applications

Julia Compart, Aakanksha Singh, Joerg Fettke, Ardha Apriyanto · 2023

Starch has been a convenient, economically important polymer with substantial applications in the food and processing industry. However, native starches present restricted applications, which hinder their industrial usage. Therefore, modification of starch is carried out to augment the positive characteristics and eliminate the limitations of the native starches. Modifications of starch can result in generating novel polymers with numerous functional and value-added properties that suit the needs of the industry. Here, we summarize the possible starch modifications in planta and outside the pl…

Polymers217 citationsDOI

Exploring Therapeutic Potential of Catalase: Strategies in Disease Prevention and Management

Shehwaz Anwar, Faris Alrumaihi, Tarique Sarwar, Ali Yousif Babiker and 3 more · 2024

The antioxidant defense mechanisms play a critical role in mitigating the deleterious effects of reactive oxygen species (ROS). Catalase stands out as a paramount enzymatic antioxidant. It efficiently catalyzes the decomposition of hydrogen peroxide (H2O2) into water and oxygen, a potentially harmful byproduct of cellular metabolism. This reaction detoxifies H2O2 and prevents oxidative damage. Catalase has been extensively studied as a therapeutic antioxidant. Its applications range from direct supplementation in conditions characterized by oxidative stress to gene therapy approaches to enhanc…

Biomolecules215 citationsDOI

Zinc Toxicity: Understanding the Limits

Hannah Schoofs, Joyce Schmit, Lothar Rink · 2024

Zinc, a vital trace element, holds significant importance in numerous physiological processes within the body. It participates in over 300 enzymatic reactions, metabolic functions, regulation of gene expression, apoptosis and immune modulation, thereby demonstrating its essential role in maintaining overall health and well-being. While zinc deficiency is associated with significant health risks, an excess of this trace element can also lead to harmful effects. According to the World Health Organization (WHO), 6.7 to 15 mg per day are referred to be the dietary reference value. An excess of the…

Molecules214 citationsDOI

The Role of Zinc in Bone Tissue Health and Regeneration—a Review

Magda Molenda, Joanna Kolmas · 2023

Zinc is a micronutrient of key importance for human health. An increasing number of studies indicate that zinc plays a significant role in bone tissue's normal development and maintaining homeostasis. Zinc is not only a component of bone tissue but is also involved in the synthesis of the collagen matrix, mineralization, and bone turnover. It has been demonstrated that zinc can stimulate runt-related transcription factor 2 (Runx2) and promote the differentiation of osteoblasts. On the other hand, zinc has been found to inhibit osteoclast-like cell formation and to decrease bone resorption by s…

Biological Trace Element Research204 citationsDOI

Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021

Hmwe Hmwe Kyu, Avina Vongpradith, Regina-Mae Villanueva Dominguez, Jianing Ma and 96 more · 2024

BACKGROUND: Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age groups of children younger than 5 years are scarce, and the burden in children older than 5 years and in adults is also understudied. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to assess the burden of, and trends in, diarrhoeal diseases overall and attributable to 13 pathogens, as well as the contributions of associated risk facto…

The Lancet Infectious Diseases201 citationsDOI

WHO world malaria report 2024

Priya Venkatesan · 2025

On Dec 11, 2024, WHO published their annual report on global trends in malaria control and elimination. The data show that, despite progress in malaria control, including routine immunisations, the number of cases in 2023 still exceeded that of 2022 by around 11 million.…

The Lancet Microbe201 citationsDOI

Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

Máté Maus, Vanessa López-Polo, Lídia Mateo, Miguel Lafarga and 23 more · 2023

Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through their secretome, known as senescence-associated secretory phenotype (SASP). Here, we report that cellular senescence, and multiple types of fibrotic diseases in mice and humans are characterized by the accumulation of iron. We show that vascular and hemolytic injuries are efficient in triggering iron accumulation, which in turn can cause senescence and promote fibrosis. Notably, we find that…

Nature Metabolism200 citationsDOI

The molecular mechanisms of cuproptosis and its relevance to cardiovascular disease

Di Wang, Zhenyu Tian, Peng Zhang, LV Zhen and 5 more · 2023

Recently, cuproptosis has been demonstrated to be a new non-apototic cell death mode that is characterized by copper dependence and the regulation of mitochondrial respiration. Cuproptosis is distinct from known cell death modes such as apoptosis, necrosis, pyroptosis, or ferroptosis. Excessive copper induces cuproptosis by promoting protein toxic stress reactions via copper-dependent anomalous oligomerization of lipoylation proteins in the tricarboxylic acid (TCA) cycle and reducing iron-sulfur cluster protein levels. Ferredoxin1 (FDX1) promotes dihydrolipoyl transacetylase (DLAT) lipoacylati…

Biomedicine & Pharmacotherapy196 citationsDOI

A review on selenium nanoparticles and their biomedical applications

K.K. Karthik, Binoy Varghese Cheriyan, S. Rajeshkumar, Meenaloshini Gopalakrishnan · 2023

Nanotechnology has enormous promise for a wide range of applications in biology. Nanoparticles (NPs) have the benefit of improving bioactivity, decreasing toxicity, allowing for precision targeting, and modulating the release profile of encapsulated compounds. Nanomaterials' unique qualities, such as their tiny size, biocompatibility, and ability to cross cell membranes for drug administration, make them useful in a variety of biological applications. Selenium (Se), a critical trace element, stands out among these nanoparticles due to its specific bioactivities in nano forms. Selenium is incor…

Biomedical Technology181 citationsDOI

Application of Agri-Food By-Products in the Food Industry

Roxana Nicoleta Rațu, Ionuţ Dumitru Veleşcu, Florina Stoica, Alexandru Usturoi and 8 more · 2023

Every year, the global food industry produces a significant number of wastes and by-products from a variety of sources. By-products from the food-processing sector are produced in large quantities, and because of their undesirable qualities, they are frequently wasted, losing important resources. In order to pursue a circular economy that refers to waste reduction and effective waste management, by-products valorization recently received increased interest. By-products are rich in bioactive compounds and can be used in various industrial applications for health promotion and nutritional benefi…

Agriculture181 citationsDOI

The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm

Thi Thuy Tien Vo, Tzu‐Yu Peng, Thi Hong Nguyen, Trang Ngoc Huyen Bui and 5 more · 2024

Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal involved in redox reactions, contributing to the generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated in different types of regulated cell death. The recent discovery of cuproptosis, a copper-dependent regulated cell death pathway that is distinct from other known regulated cell death forms, has raised interest to researchers in the field of cancer therapy. Herei…

Cell Communication and Signaling177 citationsDOI

Plant starch extraction, modification, and green applications: a review

Ahmed K. Rashwan, Hala A. Younis, Asem M. Abdelshafy, Ahmed I. Osman and 3 more · 2024

Abstract Fossil fuel-based products should be replaced by products derived from modern biomass such as plant starch, in the context of the future circular economy. Starch production globally surpasses 50 million tons annually, predominantly sourced from maize, rice, and potatoes. Here, we review plant starch with an emphasis on structure and properties, extraction, modification, and green applications. Modification techniques comprise physical, enzymatic, and genetic methods. Applications include stabilization of food, replacement of meat, three-dimensional food printing, prebiotics, encapsula…

Environmental Chemistry Letters177 citationsDOI