BiomedicalPublications

What medicine is citing right now

The 40 most-cited open-access medicine papers published since 2023. Every one is free to read, and each links to the journal that published it — so you can see what that venue costs to publish in while you are there.

Ranked by citations recorded in OpenAlex. The leading paper here has 24,849. Citation counts favour older papers, so treat this as what the field is building on, not what is newest.

Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Mathieu Laversanne, Hyuna Sung, Jacques Ferlay and 3 more · 2024

This article presents global cancer statistics by world region for the year 2022 based on updated estimates from the International Agency for Research on Cancer (IARC). There were close to 20 million new cases of cancer in the year 2022 (including nonmelanoma skin cancers [NMSCs]) alongside 9.7 million deaths from cancer (including NMSC). The estimates suggest that approximately one in five men or women develop cancer in a lifetime, whereas around one in nine men and one in 12 women die from it. Lung cancer was the most frequently diagnosed cancer in 2022, responsible for almost 2.5 million ne…

CA A Cancer Journal for Clinicians24,849 citationsDOI

Cancer statistics, 2023

Rebecca L. Siegel, Kimberly D. Miller, Nikita Sandeep Wagle, Ahmedin Jemal · 2023

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using incidence data collected by central cancer registries and mortality data collected by the National Center for Health Statistics. In 2023, 1,958,310 new cancer cases and 609,820 cancer deaths are projected to occur in the United States. Cancer incidence increased for prostate cancer by 3% annually from 2014 through 2019 after two decades of decline, translating to an additional 99,000 new cases…

CA A Cancer Journal for Clinicians16,899 citationsDOI

Cancer statistics, 2024

Rebecca L. Siegel, Angela N. Giaquinto, Ahmedin Jemal · 2024

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using incidence data collected by central cancer registries (through 2020) and mortality data collected by the National Center for Health Statistics (through 2021). In 2024, 2,001,140 new cancer cases and 611,720 cancer deaths are projected to occur in the United States. Cancer mortality continued to decline through 2021, averting over 4 million deaths since 1991 because of reductions in smoking, ea…

CA A Cancer Journal for Clinicians9,324 citationsDOI

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Masayuki Teramoto, Damian Santomauro, Amirali Aali, Yohannes Abate and 96 more · 2024

BACKGROUND: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate more rigorous monitoring of progress towards national and international health t…

The Lancet4,777 citationsDOI

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

Kanyin Liane Ong, Lauryn K Stafford, Susan A. McLaughlin, Edward J. Boyko and 96 more · 2023

BACKGROUND: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. MET…

The Lancet4,517 citationsDOI

Opinion Paper: “So what if ChatGPT wrote it?” Multidisciplinary perspectives on opportunities, challenges and implications of generative conversational AI for research, practice and policy

Yogesh K. Dwivedi, Nir Kshetri, Laurie Hughes, Emma Slade and 69 more · 2023

Transformative artificially intelligent tools, such as ChatGPT, designed to generate sophisticated text indistinguishable from that produced by a human, are applicable across a wide range of contexts. The technology presents opportunities as well as, often ethical and legal, challenges, and has the potential for both positive and negative impacts for organisations, society, and individuals. Offering multi-disciplinary insight into some of these, this article brings together 43 contributions from experts in fields such as computer science, marketing, information systems, education, policy, hosp…

International Journal of Information Management4,039 citationsDOI

Colorectal cancer statistics, 2023

Rebecca L. Siegel, Nikita Sandeep Wagle, Andrea Cercek, Robert A. Smith and 1 more · 2023

Colorectal cancer (CRC) is the second most common cause of cancer death in the United States. Every 3 years, the American Cancer Society provides an update of CRC statistics based on incidence from population-based cancer registries and mortality from the National Center for Health Statistics. In 2023, approximately 153,020 individuals will be diagnosed with CRC and 52,550 will die from the disease, including 19,550 cases and 3750 deaths in individuals younger than 50 years. The decline in CRC incidence slowed from 3%-4% annually during the 2000s to 1% annually during 2011-2019, driven partly…

CA A Cancer Journal for Clinicians3,869 citationsDOI

Performance of ChatGPT on USMLE: Potential for AI-assisted medical education using large language models

Tiffany H. Kung, Morgan Cheatham, Arielle Medenilla, Czarina Sillos and 7 more · 2023

We evaluated the performance of a large language model called ChatGPT on the United States Medical Licensing Exam (USMLE), which consists of three exams: Step 1, Step 2CK, and Step 3. ChatGPT performed at or near the passing threshold for all three exams without any specialized training or reinforcement. Additionally, ChatGPT demonstrated a high level of concordance and insight in its explanations. These results suggest that large language models may have the potential to assist with medical education, and potentially, clinical decision-making.…

PLOS Digital Health3,731 citationsDOI

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension

Giuseppe Mancia, Reinhold Kreutz, Mattias Brunström, Michel Burnier and 55 more · 2023

DOCUMENT REVIEWERS: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis (Greece), Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine (Turkey), Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering (Poland), Sang Hyun Ihm (South Korea), Uday Jadhav (India), Manolis Kallistratos (Gre…

Journal of Hypertension3,263 citationsDOI

2023 Alzheimer's disease facts and figures

Authors not listed · 2023

This article describes the public health impact of Alzheimer's disease, including prevalence and incidence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society. The Special Report examines the patient journey from awareness of cognitive changes to potential treatment with drugs that change the underlying biology of Alzheimer's. An estimated 6.7 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060 barring the development of medical breakthroughs to…

Alzheimer s & Dementia3,197 citationsDOI

A multisociety Delphi consensus statement on new fatty liver disease nomenclature

Mary E. Rinella, Jeffrey V. Lazarus, Vlad Ratziu, Sven Francque and 50 more · 2023

The principal limitations of the terms NAFLD and NASH are the reliance on exclusionary confounder terms and the use of potentially stigmatising language. This study set out to determine if content experts and patient advocates were in favor of a change in nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. The consensus was defined a priori as a supermajority (67%) vote. An independent committee of experts external to the nomenclature process made the final recommendation on the acronym and its diagnostic criteria. A total of 236 pa…

Hepatology3,072 citationsDOI

The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines

Catrin Sohrabi, Ginimol Mathew, Maria Nicola, Ahmed Kerwan and 3 more · 2023

BACKGROUND: The Surgical CAse REport (SCARE) guidelines were first published in 2016 as a tool for surgeons to document and report their surgical cases in a standardised and comprehensive manner. However, with advances in technology and changes in the healthcare landscape, it is important to revise and update these guidelines to ensure they remain relevant and valuable for surgeons. MATERIALS AND METHODS: The updated guidelines were produced through a Delphi consensus exercise. Members of the SCARE 2020 guidelines Delphi group, editorial board members, and peer reviewers were invited to partic…

International Journal of Surgery3,068 citationsDOI

Revolutionizing healthcare: the role of artificial intelligence in clinical practice

Shuroug A. Alowais, Sahar S. Alghamdi, Nada Alsuhebany, Tariq Alqahtani and 9 more · 2023

INTRODUCTION: Healthcare systems are complex and challenging for all stakeholders, but artificial intelligence (AI) has transformed various fields, including healthcare, with the potential to improve patient care and quality of life. Rapid AI advancements can revolutionize healthcare by integrating it into clinical practice. Reporting AI's role in clinical practice is crucial for successful implementation by equipping healthcare providers with essential knowledge and tools. RESEARCH SIGNIFICANCE: This review article provides a comprehensive and up-to-date overview of the current state of AI in…

BMC Medical Education2,988 citationsDOI

TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods

Professor Gary S. Collins, Karel G.M. Moons, Paula Dhiman, Richard D Riley and 30 more · 2024

The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) statement was published in 2015 to provide the minimum reporting recommendations for studies developing or evaluating the performance of a prediction model. Methodological advances in the field of prediction have since included the widespread use of artificial intelligence (AI) powered by machine learning methods to develop prediction models. An update to the TRIPOD statement is thus needed. TRIPOD+AI provides harmonised guidance for reporting prediction model studies, irrespective of w…

BMJ2,927 citationsDOI

A multisociety Delphi consensus statement on new fatty liver disease nomenclature

Mary E. Rinella, Jeffrey V. Lazarus, Vlad Ratziu, Sven Francque and 49 more · 2023

The principal limitations of the terms NAFLD and NASH are the reliance on exclusionary confounder terms and the use of potentially stigmatising language. This study set out to determine if content experts and patient advocates were in favour of a change in nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. The consensus was defined a priori as a supermajority (67%) vote. An independent committee of experts external to the nomenclature process made the final recommendation on the acronym and its diagnostic criteria. A total of 236 p…

Journal of Hepatology2,898 citationsDOI

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

A. Michael Lincoff, Kirstine Brown‐Frandsen, Helen M. Colhoun, John Deanfield and 12 more · 2023

BACKGROUND: Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to reduce the risk of adverse cardiovascular events in patients with diabetes. Whether semaglutide can reduce cardiovascular risk associated with overweight and obesity in the absence of diabetes is unknown. METHODS: In a multicenter, double-blind, randomized, placebo-controlled, event-driven superiority trial, we enrolled patients 45 years of age or older who had preexisting cardiovascular disease and a body-mass index (the weight in kilograms divided by the square of the height in meters) of 27 or greater but…

New England Journal of Medicine2,875 citationsDOI

Cancer statistics, 2025

Rebecca L. Siegel, Tyler B. Kratzer, Angela N. Giaquinto, Hyuna Sung and 1 more · 2025

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using incidence data collected by central cancer registries (through 2021) and mortality data collected by the National Center for Health Statistics (through 2022). In 2025, 2,041,910 new cancer cases and 618,120 cancer deaths are projected to occur in the United States. The cancer mortality rate continued to decline through 2022, averting nearly 4.5 million deaths since 1991 because of smoking redu…

CA A Cancer Journal for Clinicians2,798 citationsDOI

Donanemab in Early Symptomatic Alzheimer Disease

John R. Sims, Jennifer A. Zimmer, Cynthia Evans, Ming‐Chi Lu and 96 more · 2023

Importance: There are limited efficacious treatments for Alzheimer disease. Objective: To assess efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid plaque. Design, Setting, and Participants: Multicenter (277 medical research centers/hospitals in 8 countries), randomized, double-blind, placebo-controlled, 18-month phase 3 trial that enrolled 1736 participants with early symptomatic Alzheimer disease (mild cognitive impairment/mild dementia) with amyloid and low/medium or high tau pathology based on positron emission tomography imaging from June 2020 to Novembe…

JAMA2,749 citationsDOI

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Masayuki Teramoto, Kanyin Liane Ong, Amirali Aali, Hazim Ababneh and 96 more · 2024

BACKGROUND: Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of…

The Lancet2,699 citationsDOI

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Seth S. Martin, Aaron W. Aday, Zaid Almarzooq, Cheryl A.M. Anderson and 39 more · 2024

BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (includin…

Circulation2,594 citationsDOI

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

José A. Joglar, Mina K. Chung, Anastasia L. Armbruster, Emelia J. Benjamin and 30 more · 2023

AIM: The "2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation" provides recommendations to guide clinicians in the treatment of patients with atrial fibrillation. METHODS: A comprehensive literature search was conducted from May 12, 2022, to November 3, 2022, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. Additional relevant studies, published through…

Circulation2,553 citationsDOI

Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup

Clifford R. Jack, J. Scott Andrews, Thomas G. Beach, Teresa Buracchio and 16 more · 2024

The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD). The present document updates the 2018 research framework in response to several recent developments. Defining diseases biologically, rather than based on syndromic presentation, has long been standard in many areas of medicine (e.g., oncology), and is becoming a unifying concept common to all neurodegenerative diseases, not just AD. The present document is…

Alzheimer s & Dementia2,491 citationsDOI

Comparing Physician and Artificial Intelligence Chatbot Responses to Patient Questions Posted to a Public Social Media Forum

John W. Ayers, Adam Poliak, Mark Dredze, Eric C. Leas and 7 more · 2023

Importance: The rapid expansion of virtual health care has caused a surge in patient messages concomitant with more work and burnout among health care professionals. Artificial intelligence (AI) assistants could potentially aid in creating answers to patient questions by drafting responses that could be reviewed by clinicians. Objective: To evaluate the ability of an AI chatbot assistant (ChatGPT), released in November 2022, to provide quality and empathetic responses to patient questions. Design, Setting, and Participants: In this cross-sectional study, a public and nonidentifiable database o…

JAMA Internal Medicine2,470 citationsDOI

AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease

Mary E. Rinella, Brent A. Neuschwander‐Tetri, Mohammad Shadab Siddiqui, Manal F. Abdelmalek and 4 more · 2023

PREAMBLE The study of NAFLD has intensified significantly, with more than 1400 publications since 2018, when the last American Association for the Study of Liver Diseases (AASLD) Guidance document was published.1 This new AASLD Guidance document reflects many advances in the field pertinent to any practitioner caring for patients with NAFLD and emphasizes advances in noninvasive risk stratification and therapeutics. A separate guideline focused on the management of patients with NAFLD in the context of diabetes has been written jointly by the American Association of Clinical Endocrinology and…

Hepatology2,437 citationsDOI

ChatGPT: A comprehensive review on background, applications, key challenges, bias, ethics, limitations and future scope

Partha Pratim Ray · 2023

In recent years, artificial intelligence (AI) and machine learning have been transforming the landscape of scientific research. Out of which, the chatbot technology has experienced tremendous advancements in recent years, especially with ChatGPT emerging as a notable AI language model. This comprehensive review delves into the background, applications, key challenges, and future directions of ChatGPT. We begin by exploring its origins, development, and underlying technology, before examining its wide-ranging applications across industries such as customer service, healthcare, and education. We…

Internet of Things and Cyber-Physical Systems2,424 citationsDOI

2024 Alzheimer's disease facts and figures

Authors not listed · 2024

This article describes the public health impact of Alzheimer's disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care and the ramifications of AD for family caregivers, the dementia workforce and society. The Special Report discusses the larger health care system for older adults with cognitive issues, focusing on the role of caregivers and non-physician health care professionals. An estimated 6.9 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060, barring the development of med…

Alzheimer s & Dementia2,363 citationsDOI

2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Theresa A. McDonagh, Marco Metra, Marianna Adamo, Roy S. Gardner and 96 more · 2023

1. Preamble 3629 2. Introduction 3631 3. Chronic heart failure 3631 4. Acute heart failure 3634 4.1. Medical therapy 3634 4.1.1. Diuretics 3634 4.1.2. Sodium–glucose co-transporter 2 inhibitors 3634 4.2. Management strategies 3634 4.2.1. Admission phase 3634 4.2.2. Pre-discharge and early post-discharge phases 3634 5. Comorbidities 3635 5.1. Chronic kidney disease and type 2 diabetes mellitus 3635 5.1.1. Sodium–glucose co-transporter 2 inhibitors 3635 5.1.2. Finerenone 3636 5.2. Iron deficiency 3636 6. Data availability statement 3637 7. Author information 3637 8. Appendix 3638 9. References 3…

European Heart Journal2,362 citationsDOI

Chatting and cheating: Ensuring academic integrity in the era of ChatGPT

Debby Cotton, Peter A. Cotton, J. Reuben Shipway · 2023

The use of artificial intelligence in academia is a hot topic in the education field. ChatGPT is an AI tool that offers a range of benefits, including increased student engagement, collaboration, and accessibility. However, is also raises concerns regarding academic honesty and plagiarism. This paper examines the opportunities and challenges of using ChatGPT in higher education, and discusses the potential risks and rewards of these tools. The paper also considers the difficulties of detecting and preventing academic dishonesty, and suggests strategies that universities can adopt to ensure eth…

Innovations in Education and Teaching International2,271 citationsDOI

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Nowell H Phelps, Rosie Singleton, Bin Zhou, Rachel A Heap and 96 more · 2024

BACKGROUND: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. METHODS: ). For school-aged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference) and obesity (BMI >2 SD above the median). FINDINGS: From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11…

The Lancet2,254 citationsDOI

Cancer incidence and mortality in China, 2022

Bingfeng Han, Rongshou Zheng, Hongmei Zeng, Shaoming Wang and 5 more · 2024

Background: The National Cancer Center (NCC) of China regularly reports the nationwide statistics on cancer incidence and mortality in China. The International Agency for Research on Cancer (IARC) calculates and publishes the cancer burden of countries around the world every two years. To ensure consistency between the actual surveillance data in China and the data published by IARC, NCC has received approval from the National Health Commission and IARC to simultaneously release the cancer burden data for China in GLOBOCAN 2022. Methods: There were a total of 700 registries reporting high-qual…

Journal of the National Cancer Center2,156 citationsDOI

Global burden of liver disease: 2023 update

Harshad Devarbhavi, Sumeet K. Asrani, Juan Pablo Arab, Yvonne Ayerki Nartey and 2 more · 2023

Liver disease accounts for two million deaths annually and is responsible for 4% of all deaths (1 out of every 25 deaths worldwide); approximately two-thirds of all liver-related deaths occur in men. Deaths are largely attributable to complications of cirrhosis and hepatocellular carcinoma, with acute hepatitis accounting for a smaller proportion of deaths. The most common causes of cirrhosis worldwide are related to viral hepatitis, alcohol, and non-alcoholic fatty liver disease. Hepatotropic viruses are the aetiological factor in most cases of acute hepatitis, but drug-induced liver injury i…

Journal of Hepatology2,126 citationsDOI