BiomedicalPublications

What dentistry is citing right now

The 40 most-cited open-access dentistry papers published since 2023. Every one is free to read, and each links to the journal that published it — so you can see what that venue costs to publish in while you are there.

Ranked by citations recorded in OpenAlex. The leading paper here has 770. Citation counts favour older papers, so treat this as what the field is building on, not what is newest.

Oral squamous cell carcinomas: state of the field and emerging directions

Yunhan Tan, Zhihan Wang, Mengtong Xu, Bowen Li and 5 more · 2023

Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral cavity. It accounts for approximately 90% of oral malignancies and impairs appearance, pronunciation, swallowing, and flavor perception. In 2020, 377,713 OSCC cases were reported globally. According to the Global Cancer Observatory (GCO), the incidence of OSCC will rise by approximately 40% by 2040, accompanied by a growth in mortality. Persistent exposure to various risk factors, including tobacco, alcohol, betel quid (BQ), and human papillomavirus (HPV), will lead to the development of oral potentially maligna…

International Journal of Oral Science770 citationsDOI

Prevention and treatment of peri‐implant diseases—The <scp>EFP S3</scp> level clinical practice guideline

David Herrera, Tord Berglundh, Frank Schwarz, Iain Chapple and 7 more · 2023

BACKGROUND: The recently published Clinical Practice Guidelines (CPGs) for the treatment of stages I-IV periodontitis provided evidence-based recommendations for treating periodontitis patients, defined according to the 2018 classification. Peri-implant diseases were also re-defined in the 2018 classification. It is well established that both peri-implant mucositis and peri-implantitis are highly prevalent. In addition, peri-implantitis is particularly challenging to manage and is accompanied by significant morbidity. AIM: To develop an S3 level CPG for the prevention and treatment of peri-imp…

Journal Of Clinical Periodontology449 citationsDOI

Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021

Eduardo Bernabé, Wagner Marcenes, Rizwan Suliankatchi Abdulkader, Lucas Guimarães Abreu and 96 more · 2025

BACKGROUND: The WHO Global Oral Health Action Plan has set an overarching global target of achieving a 10% reduction in the prevalence of oral conditions by 2030. Robust and up-to-date information on the global burden of oral conditions is paramount to monitor progress towards this target. The aim of this systematic data analysis was to produce global, WHO region, and country-level estimates of the prevalence of, and disability-adjusted life-years (DALYs) attributed to, untreated caries, severe periodontitis, edentulism, other oral disorders, lip and oral cavity cancer, and orofacial clefts fr…

The Lancet364 citationsDOI

Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis

Ali A. Abdulkareem, Firas Bashir Hashim Al-Taweel, Ali J. B. Al-Sharqi, Sarhang Gul and 2 more · 2023

The primary etiological agent for the initiation and progression of periodontal disease is the dental plaque biofilm which is an organized aggregation of microorganisms residing within a complex intercellular matrix. The non-specific plaque hypothesis was the first attempt to explain the role of the dental biofilm in the pathogenesis of periodontal diseases. However, the introduction of sophisticated diagnostic and laboratory assays has led to the realisation that the development of periodontitis requires more than a mere increase in the biomass of dental plaque. Indeed, multispecies biofilms…

Journal of Oral Microbiology356 citationsDOI

Burden of severe periodontitis and edentulism in 2021, with projections up to 2050: The Global Burden of Disease 2021 study

Gustavo G. Nascimento, Silas Alves‐Costa, Mario Romandini · 2024

AIM: To (i) assess the prevalence, incidence, and burden of severe periodontitis and edentulism in 2021, and (ii) forecast their rates in 2050. METHODS: Prevalence, incidence, and Years Lived with Disability (YLDs) for severe periodontitis and edentulism in 2021 were gathered globally, covering 204 countries, seven super regions, and 21 regions from the Global Burden of Disease (GBD) 2021 study. Prevalence, incidence, and YLDs due to periodontitis and edentulism to 2050 were projected using mixed-effects models with the socio-demographic index as the main covariate. RESULTS: In 2021, over 1 bi…

Journal of Periodontal Research353 citationsDOI

<scp>WHO</scp>'s global oral health status report 2022: Actions, discussion and implementation

Nityanand Jain, Upasna Dutt, Igor Radenkov, Shivani Jain · 2023

The Global Oral Health Status Report (GOHSR) directed towards the promotion and achievement of the universal health coverage (UHC) for oral health by the year 2030 was published by the World Health Organization (WHO) in November 2022. The report reviews the latest evidence-based data on the status of oral health worldwide in terms of oral disease burden, risk factors, distributions of dental practitioners, health benefits package and the national health response for oral health crises (World Health Organization, 2022). The first of its kind report aims to foster discussion and implementation o…

Oral Diseases339 citationsDOI

Factors that affect the outcomes of root canal treatment and retreatment—A reframing of the principles

K. Gulabivala, Y.‐L. Ng · 2023

This paper undertakes a broad and comprehensive synthesis of relevant clinical, biological, biomechanical, technical and healthcare services data to understand the factors affecting outcomes of periapical healing after root canal (re)treatment. The medical and dental evidence-based era (1980-present) is contextualized with the earlier evidence drive in endodontics (1911-1940) triggered by the focal infection era. The current evidence-based approach has a sharper focus on evidence quality and derivation of practice guidelines. Contrary views question whether guideline-driven, or expertise-devel…

International Endodontic Journal276 citationsDOI

Artificial intelligence in dentistry—A review

Hao Ding, Jiamin Wu, Wuyuan Zhao, JP Matinlinna and 2 more · 2023

Artificial Intelligence (AI) is the ability of machines to perform tasks that normally require human intelligence. AI is not a new term, the concept of AI can be dated back to 1950. However, it did not become a practical tool until two decades ago. Owing to the rapid development of three cornerstones of current AI technology-big data (coming through digital devices), computational power, and AI algorithm-in the past two decades, AI applications have started to provide convenience to people's lives. In dentistry, AI has been adopted in all dental disciplines, i.e., operative dentistry, periodon…

Frontiers in Dental Medicine265 citationsDOI

Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (<scp>EFP</scp>) and the European arm of the World Organization of Family Doctors (<scp>WONCA</scp> Europe)

David Herrera, Mariano Sanz, Lior Shapira, Carlos Brotons and 14 more · 2023

AIM: To explore the implications for dentists and family doctors of the association between periodontal and systemic diseases and the role of dentists and family doctors in managing non-communicable diseases (NCDs) and promoting healthy lifestyles. MATERIALS AND METHODS: The consensus reports of the previous Focused Workshops on the associations between periodontitis and diabetes (2017) and periodontitis and cardiovascular diseases (2019) formed the technical reviews to underpin discussions on both topics. For the association with respiratory diseases, a systematic review was specifically comm…

Journal Of Clinical Periodontology262 citationsDOI

The Evolving Microbiome of Dental Caries

Grace Spatafora, Yihong Li, Xuesong He, Annie Cowan and 1 more · 2024

Dental caries is a significant oral and public health problem worldwide, especially in low-income populations. The risk of dental caries increases with frequent intake of dietary carbohydrates, including sugars, leading to increased acidity and disruption of the symbiotic diverse and complex microbial community of health. Excess acid production leads to a dysbiotic shift in the bacterial biofilm composition, demineralization of tooth structure, and cavities. Highly acidic and acid-tolerant species associated with caries include Streptococcus mutans, Lactobacillus, Actinomyces, Bifidobacterium,…

Microorganisms261 citationsDOI

Treatment of pulpal and apical disease: The European Society of Endodontology (ESE) S3‐level clinical practice guideline

Henry F. Duncan, Lise‐Lotte Kirkevang, Ove A. Peters, Ikhlas El Karim and 7 more · 2023

BACKGROUND: The ESE previously published quality guidelines for endodontic treatment in 2006; however, there have been significant changes since not only in clinical endodontics but also in consensus and guideline development processes. In the development of the inaugural S3-level clinical practice guidelines (CPG), a comprehensive systematic and methodologically robust guideline consultation process was followed in order to produce evidence-based recommendations for the management of patients presenting with pulpal and apical disease. AIM: To develop an S3-level CPG for the treatment of pulpa…

International Endodontic Journal259 citationsDOI

Bone Grafts in Dental Medicine: An Overview of Autografts, Allografts and Synthetic Materials

María Pía Ferraz · 2023

This review provides an overview of various materials used in dentistry and oral and maxillofacial surgeries to replace or repair bone defects. The choice of material depends on factors such as tissue viability, size, shape, and defect volume. While small bone defects can regenerate naturally, extensive defects or loss or pathological fractures require surgical intervention and the use of substitute bones. Autologous bone, taken from the patient's own body, is the gold standard for bone grafting but has drawbacks such as uncertain prognosis, surgery at the donor site, and limited availability.…

Materials244 citationsDOI

Oral Microbiome: A Review of Its Impact on Oral and Systemic Health

John J. Rajasekaran, Hari Krishnan Krishnamurthy, Jophi Bosco, Vasanth Jayaraman and 3 more · 2024

PURPOSE OF REVIEW: This review investigates the oral microbiome's composition, functions, influencing factors, connections to oral and systemic diseases, and personalized oral care strategies. RECENT FINDINGS: The oral microbiome is a complex ecosystem consisting of bacteria, fungi, archaea, and viruses that contribute to oral health. Various factors, such as diet, smoking, alcohol consumption, lifestyle choices, and medical conditions, can affect the balance of the oral microbiome and lead to dysbiosis, which can result in oral health issues like dental caries, gingivitis, periodontitis, oral…

Microorganisms215 citationsDOI

The Transformative Role of Artificial Intelligence in Dentistry: A Comprehensive Overview. Part 1: Fundamentals of AI, and its Contemporary Applications in Dentistry

Lakshman P. Samaranayake, Nozimjon Tuygunov, Falk Schwendicke, Thanaphum Osathanon and 3 more · 2025

Artificial intelligence (AI) holds immense promise in revolutionising dentistry, spanning, diagnostics, treatment planning and educational realms. This narrative review, in two parts, explores the fundamentals and the multifaceted potential of AI in dentistry. The current article explores the profound impact of AI in dentistry, encompassing diagnostic tools, treatment planning, and patient care. The Part 2 of the article delves into the potential of AI in patient education, ethics and the FDI communique on AI in dentistry. The review begins by elucidating the historical context of AI, outlinin…

International Dental Journal199 citationsDOI

Periodontal disease: A systemic condition

German Eduardo Miguel Villoria, Ricardo Guimarães Fischer, Eduardo Muniz Barretto Tinoco, Joerg Meyle and 1 more · 2024

For decades, periodontitis has been considered to be a local inflammatory disease of the periodontal tissues in the oral cavity. Initially, associations of periodontitis with a multitude of noncommunicable diseases were each studied separately, and relationships were shown. The associations of periodontitis with morbidities, such as cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, respiratory diseases, have been demonstrated. As most such studies were cross-sectional in nature, questions about causality cannot be univocally answered. And periodontitis as an independent risk fa…

Periodontology 2000190 citationsDOI

A comprehensive review of the application of probiotics and postbiotics in oral health

Aziz Homayouni Rad, Hadi Pourjafar, Esmaeel Mirzakhani · 2023

Oral diseases are among the most common diseases around the world that people usually suffer from during their lifetime. Tooth decay is a multifactorial disease, and the composition of oral microbiota is a critical factor in its development. Also, Streptococcus mutans is considered the most important caries-causing species. It is expected that probiotics, as they adjust the intestinal microbiota and reduce the number of pathogenic bacteria in the human intestine, can exert their health-giving effects, especially the anti-pathogenic effect, in the oral cavity, which is part of the human gastroi…

Frontiers in Cellular and Infection Microbiology178 citationsDOI

Full-length 16S rRNA gene sequencing by PacBio improves taxonomic resolution in human microbiome samples

Elena Buetas, M. Jordán-López, Andrés López‐Roldán, Giuseppe D’Auria and 4 more · 2024

BACKGROUND: Sequencing variable regions of the 16S rRNA gene (≃300 bp) with Illumina technology is commonly used to study the composition of human microbiota. Unfortunately, short reads are unable to differentiate between highly similar species. Considering that species from the same genus can be associated with health or disease it is important to identify them at the lowest possible taxonomic rank. Third-generation sequencing platforms such as PacBio SMRT, increase read lengths allowing to sequence the whole gene with the maximum taxonomic resolution. Despite its potential, full length 16S r…

BMC Genomics166 citationsDOI

The Bidirectional Relationship between Periodontal Disease and Diabetes Mellitus—A Review

Ioana Păunică, Marina Cristina Giurgiu, Anca Silvia Dumitriu, Stana Păunica and 3 more · 2023

Periodontitis is a chronic inflammatory disease caused by the presence of a bacterial biofilm known as dental plaque. This biofilm affects the supporting apparatus of the teeth, especially the periodontal ligaments and the bone surrounding the teeth. Periodontal disease and diabetes seem to be interrelated and in a bidirectional relationship, and have been increasingly studied in recent decades. For example, diabetes mellitus has a detrimental effect on periodontal disease, increasing its prevalence, extent, and severity. In turn, periodontitis negatively affects glycemic control and the cours…

Diagnostics163 citationsDOI

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi Kahraman Gürsoy and 2 more · 2023

This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis-centered interpretation. Reference is made to anerobic microbiology and to the discovery of select periodontal pathogens and their virulence factors, as well as to biofilms. The evolution of contemporary molecular methods and high-throughput platforms is highlighted in appreciating the breadth and depth of…

Periodontology 2000163 citationsDOI

Dental Luting Cements: An Updated Comprehensive Review

Artak Heboyan, Anna Vardanyan, Mohmed Isaqali Karobari, Anand Marya and 5 more · 2023

The cementation of indirect restoration is one of the most important steps in prosthetic and restorative dentistry. Cementation aims to bond the prosthetic restoration to the prepared enamel or enamel and dentine. Successful cementation protocols prevent biofilm formation at the margin between tooth and restoration and minimize mechanical and biological complications. With the advancements in dental cements, they have been modified to be versatile in terms of handling, curing, and bond strengths. This review presents updates on dental cements, focusing on the composition, properties, advantage…

Molecules162 citationsDOI

Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets

Nicole Neurath, Marco Kesting · 2024

Chronic inflammatory processes in the oral mucosa and periodontitis are common disorders caused by microflora and microbial biofilms. These factors activate both the innate and adaptive immune systems, leading to the production of pro-inflammatory cytokines. Cytokines are known to play a crucial role in the pathogenesis of gingivitis and periodontitis and have been proposed as biomarkers for diagnosis and follow-up of these diseases. They can activate immune and stromal cells, leading to local inflammation and tissue damage. This damage can include destruction of the periodontal ligaments, gin…

Frontiers in Immunology161 citationsDOI

Progress in Dental Adhesive Materials

Milena Cadenaro, Uroš Josić, Tatjana Maravić, Claudia Mazzitelli and 4 more · 2023

There have been significant advances in adhesive dentistry in recent decades, with efforts being made to improve the mechanical and bonding properties of resin-based dental adhesive materials. Various attempts have been made to achieve versatility, introducing functional monomers and silanes into the materials' composition to enable the chemical reaction with tooth structure and restorative materials and a multimode use. The novel adhesive materials also tend to be simpler in terms of clinical use, requiring reduced number of steps, making them less technique sensitive. However, these material…

Journal of Dental Research155 citationsDOI

Polymeric Denture Base Materials: A Review

Ahmed Yaseen Alqutaibi, Abdulmajeed Baik, Sarah Almuzaini, Ahmed E. Farghal and 6 more · 2023

An ideal denture base must have good physical and mechanical properties, biocompatibility, and esthetic properties. Various polymeric materials have been used to construct denture bases. Polymethyl methacrylate (PMMA) is the most used biomaterial for dentures fabrication due to its favorable properties, which include ease of processing and pigmenting, sufficient mechanical properties, economy, and low toxicity. This article aimed to comprehensively review the current knowledge about denture base materials (DBMs) types, properties, modifications, applications, and construction methods. We searc…

Polymers153 citationsDOI

The Role of Fusobacterium nucleatum in Oral and Colorectal Carcinogenesis

Pamela Pignatelli, Federica Nuccio, Adriano Piattelli, Maria Cristina Curia · 2023

In recent years, several studies have suggested a strong association of microorganisms with several human cancers. Two periodontopathogenic species in particular have been mentioned frequently: Fusobacterium nucleatum (F. nucleatum) and Porphyromonas gingivalis. Chronic periodontal disease has been reported to be a risk factor for oral squamous cell carcinoma (OSCC), colorectal cancer (CRC) and pancreatic cancer. F. nucleatum is a Gram-negative anaerobic bacterium that lives in the oral cavity, urogenital, intestinal and upper digestive tract. It plays a significant role as a co-aggregation fa…

Microorganisms149 citationsDOI

Predictability of orthodontic tooth movement with aligners: effect of treatment design

Tommaso Castroflorio, Ambra Sedran, Simone Parrini, Francesco Garino and 6 more · 2023

Abstract Backgrounds The present study was designed to define: (1) which are the less predictable OTM with Invisalign aligners when the treatment plan is designed by expert operators, (2) if the presence and shape of attachments influence the predictability of OTM and (3) if patients’ demographics influence OTM predictability. The sample comprises 79 prospectively recruited patients (mean age 30.8 years; SD 12.0; 23 M, 56 F), treated by expert operators with an average of 27 aligners (SD 15) in the maxillary arch and 25 aligners (SD 11) in the mandibular arch. Post-treatment digital models and…

Progress in Orthodontics146 citationsDOI

Oral microbiota in human health and disease: A perspective

Luigì Santacroce, Pier Carmine Passarelli, Domenico Azzolino, Lucrezia Bottalico and 6 more · 2023

The evolution of medical knowledge about oral microbiota has increased awareness of its important role for the entire human body health. A wide range of microbial species colonizing the oral cavity interact both with each other and with their host through complex pathways. Usually, these interactions lead to a harmonious coexistence (i.e. eubiosis). However, several factors - including diet, poor oral hygiene, tobacco smoking, and certain medications, among others - can disrupt this weak homeostatic balance (i.e. dysbiosis) with potential implications on both oral (i.e. development of caries a…

Experimental Biology and Medicine146 citationsDOI

Irrigants and irrigation activation systems in Endodontics

Brenda Paula Figueiredo de Almeida Gomes, Emelly Aveiro, Anil Kishen · 2023

Root canal infections are typically polymicrobial and involve strong bacterial interactions. The goal of endodontic treatment is to remove infected content from the root canal system to allow the healing of a pre-existing periapical lesion or to prevent infection of the periradicular tissues. Instrumentation alone is not capable of touching all of the root canal walls. Therefore, the irrigation process is an essential step in the endodontic treatment. However, due to the complex anatomy of the root canal system, this cleaning is very challenging. Although syringe and needle irrigation associat…

Brazilian Dental Journal146 citationsDOI

Finite element analysis in implant dentistry: State of the art and future directions

Cristina Falcinelli, Francesco Valente, Marcello Vasta, Tonino Traini · 2023

OBJECTIVE: To discuss the state of the art of Finite Element (FE) modeling in implant dentistry, to highlight the principal features and the current limitations, and giving recommendations to pave the way for future studies. METHODS: The articles' search was performed through PubMed, Web of Science, Scopus, Science Direct, and Google Scholar using specific keywords. The articles were selected based on the inclusion and exclusion criteria, after title, abstract and full-text evaluation. A total of 147 studies were included in this review. RESULTS: To date, the FE analysis of the bone-dental imp…

Dental Materials130 citationsDOI

Expert consensus on irrigation and intracanal medication in root canal therapy

Xiaoying Zou, Xin Zheng, Yu-Hong Liang, Chengfei Zhang and 24 more · 2024

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. Additionally, ambiguous clinical indications for root canal medication and non-standardized dressing protocols must be clarified. Inappropriate intracanal medication may present side effects and jeopardize the therapeutic outcomes. Indeed, clinicians have…

International Journal of Oral Science129 citationsDOI

Bioceramics in Endodontics: Updates and Future Perspectives

Xu Dong, Xin Xu · 2023

Bioceramics, with excellent bioactivity and biocompatibility, have been widely used in dentistry, particularly in endodontics. Mineral trioxide aggregate (MTA) is the most widely used bioceramic in endodontics. Recently, many new bioceramics have been developed, showing good potential for the treatment of endodontic diseases. This paper reviews the characteristics of bioceramics and their applications in various clinical endodontic situations, including root-end filling, root canal therapy, vital pulp therapy, apexification/regenerative endodontic treatment, perforation repair, and root defect…

Bioengineering129 citationsDOI

How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: an oral microbiota perspective

Si-Chen Luo, Simin Wei, Xin-Tao Luo, Qiong-Qiong Yang and 3 more · 2024

Dental caries, a highly prevalent oral disease, impacts a significant portion of the global population. Conventional approaches that indiscriminately eradicate microbes disrupt the natural equilibrium of the oral microbiota. In contrast, biointervention strategies aim to restore this balance by introducing beneficial microorganisms or inhibiting cariogenic ones. Over the past three decades, microbial preparations have garnered considerable attention in dental research for the prevention and treatment of dental caries. However, unlike related pathologies in the gastrointestinal, vaginal, and re…

npj Biofilms and Microbiomes127 citationsDOI

Biomimetic approaches and materials in restorative and regenerative dentistry: review article

Lamia Singer, Ahmed Mahmoud Fouda, Christoph Bourauel · 2023

Biomimetics is a branch of science that explores the technical beauty of nature. The concept of biomimetics has been brilliantly applied in famous applications such as the design of the Eiffel Tower that has been inspired from the trabecular structure of bone. In dentistry, the purpose of using biomimetic concepts and protocols is to conserve tooth structure and vitality, increase the longevity of restorative dental treatments, and eliminate future retreatment cycles. Biomimetic dental materials are inherently biocompatible with excellent physico-chemical properties. They have been successfull…

BMC Oral Health125 citationsDOI

Role of oxidative stress in the relationship between periodontitis and systemic diseases

Jiaxin Shang, Haifeng Liu, Youli Zheng, Zheng Zhang · 2023

Periodontitis is a common inflammatory disease. It is characterized by destruction of the supporting structures of the teeth and could lead to tooth loss and systemic inflammation. Bacteria in inflamed gingival tissue and virulence factors are capable of entering the bloodstream to induce systemic inflammatory response, thus influencing the pathological process of many diseases, such as cardiovascular diseases, diabetes, chronic kidney disease, as well as liver injury. An increasing body of evidence show the complex interplay between oxidative stress and inflammation in disease pathogenesis. W…

Frontiers in Physiology124 citationsDOI

IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer’s disease

Rachel Pei‐Hsuan Wang, Jianpan Huang, Kannie W. Y. Chan, WK Leung and 3 more · 2023

BACKGROUND: Systemic activation of the immune system can exert detrimental effects on the central nervous system. Periodontitis, a chronic disease of the oral cavity, is a common source of systemic inflammation. Neuroinflammation might be a result of this to accelerate progressive deterioration of neuronal functions during aging or exacerbate pre-existing neurodegenerative diseases, such as Alzheimer's disease. With advancing age, the progressive increase in the body's pro-inflammatory status favors the state of vulnerability to both periodontitis and Alzheimer's disease. In the present study,…

Journal of Neuroinflammation123 citationsDOI

Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic

Zi‐Wei Cui, Peng Wang, Weiyue Gao · 2025

The oral microbiome comprises over 700 distinct species, forming complex biofilms essential for maintaining oral and systemic health. When the microbial homeostasis in the periodontium is disrupted, pathogens within the biofilm can cause periodontitis and peri-implantitis, inducing host immune responses. Understanding the role of microbial communities and the immune mechanisms in oral health and disease is crucial for developing improved preventive, diagnostic and therapeutic strategies. However, many questions remain about how changes in bacterial populations contribute to the development and…

Frontiers in Cellular and Infection Microbiology122 citationsDOI

Recent advances in metal nanoparticles to treat periodontitis

Kamyar Nasiri, Seyed Mohammad Reza Masoumi, Sara Amini, Mina Goudarzi and 6 more · 2023

The gradual deterioration of the supporting periodontal tissues caused by periodontitis, a chronic multifactorial inflammatory disease, is thought to be triggered by the colonization of dysbiotic plaque biofilms in a vulnerable host. One of the most prevalent dental conditions in the world, periodontitis is now the leading factor in adult tooth loss. When periodontitis does develop, it is treated by scraping the mineralized deposits and dental biofilm off the tooth surfaces. Numerous studies have shown that non-surgical treatment significantly improves clinical and microbiological indices in i…

Journal of Nanobiotechnology121 citationsDOI

Periodontal Health and Disease in the Context of Systemic Diseases

Gaetano Isola, Simona Santonocito, Saturnino Marco Lupi, Alessandro Polizzi and 3 more · 2023

During recent years, considerable progress has been made in understanding the etiopathogenesis of periodontitis in its various forms and their interactions with the host. Furthermore, a number of reports have highlighted the importance of oral health and disease in systemic conditions, especially cardiovascular diseases and diabetes. In this regard, research has attempted to explain the role of periodontitis in promoting alteration in distant sites and organs. Recently, DNA sequencing studies have revealed how oral infections can occur in distant sites such as the colon, reproductive tissues,…

Mediators of Inflammation121 citationsDOI