BiomedicalPublications

What pharmacology, toxicology and pharmaceutics is citing right now

The 40 most-cited open-access pharmacology, toxicology and pharmaceutics papers published since 2023. Every one is free to read, and each links to the journal that published it — so you can see what that venue costs to publish in while you are there.

Ranked by citations recorded in OpenAlex. The leading paper here has 650. Citation counts favour older papers, so treat this as what the field is building on, not what is newest.

Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development

Meenu Mehta, Thuỳ Anh Bùi, Xinpu Yang, Yagiz Alp Aksoy and 2 more · 2023

Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising therapeutic outcomes, thus gaining substantial interest in preclinical and clinical research. In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid nanoparticles, focusi…

ACS Materials Au650 citationsDOI

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

Nimeet Desai, Dhwani Rana, Sagar Salave, Raghav Gupta and 6 more · 2023

Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical appli…

Pharmaceutics603 citationsDOI

Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review

Cláudia Viegas, Ana B. Patrício, João Prata, Akhtar Nadhman and 2 more · 2023

Solid-lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured…

Pharmaceutics474 citationsDOI

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

Karolina Jafernik, Agata Ładniak, Eliza Blicharska, Katarzyna Czarnek and 3 more · 2023

Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that are receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They are able to encapsulate drugs as well as active compounds and deliver them to a specific place in the body providing a controlled release. In the article, an overview has been made of the most frequently used preparation methods, and the developed applications in medicine. The presentation of the most important information concerning ChNPs, especially chitosan's properties…

Molecules437 citationsDOI

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>CYP2D6</i>, <i>CYP2C19</i>, <i>CYP2B6</i>, <i>SLC6A4</i>, and <i>HTR2A</i> Genotypes and Serotonin Reuptake Inhibitor Antidepressants

Chad Bousman, James M. Stevenson, Laura B. Ramsey, Katrin Sangkuhl and 14 more · 2023

Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake inhibitors (SSRIs; i.e., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), serotonin and norepinephrine reuptake inhibitors (i.e., desvenlafaxine, duloxetine, levomilnacipran, milnacipran, and venlafaxine), and serotonin modulators with SSRI-like properties (i.e., vilazodone and vortioxetine) are primary pharmacologic treatments for major depressive and anxiety disorders. Genetic variation in CYP2D6, CYP2C19, and CYP2B6 influences the metabolism of many of these antidepressants, w…

Clinical Pharmacology & Therapeutics426 citationsDOI

Advances in Oral Drug Delivery Systems: Challenges and Opportunities

Jie Lou, Hongli Duan, Qin Qin, Zhipeng Teng and 5 more · 2023

The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavailability and targeted design of oral drug delivery system. Innovative pharmaceutical approaches including nanoparticulate formulations, biomimetic drug formulations, and microfabricated devices have been explored to optimize drug targeting and bioavailability. In this review, the anatomical factors, biochemical factors, and physiology factors that influence del…

Pharmaceutics381 citationsDOI

Opportunities and challenges in the diagnostic utility of dermal interstitial fluid

Mark Friedel, Ian A. P. Thompson, Gerald B. Kasting, Ronen Polsky and 3 more · 2023

The volume of interstitial fluid (ISF) in the human body is three times that of blood. Yet, collecting diagnostically useful ISF is more challenging than collecting blood because the extraction of dermal ISF disrupts the delicate balance of pressure between ISF, blood and lymph, and because the triggered local inflammation further skews the concentrations of many analytes in the extracted fluid. In this Perspective, we overview the most meaningful differences in the make-up of ISF and blood, and discuss why ISF cannot be viewed generally as a diagnostically useful proxy for blood. We also argu…

Nature Biomedical Engineering353 citationsDOI

Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Adaeze Linda Onugwu, Chinekwu Sherridan Nwagwu, Obinna Sabastine Onugwu, Adaeze Chidiebere Echezona and 6 more · 2023

Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease of administration and convenience. However, it remains a significant challenge to efficiently deliver drugs to the eye through this route because of various structural and physiological constraints that restrict the distribution of therapeutic molecules into the ocular tissues. The bioavailability of topically applied ocular medications such as eye drops is t…

Journal of Controlled Release341 citationsDOI

Scarless wound healing programmed by core-shell microneedles

Ying Zhang, Ying Zhang, Yinxian Yang, Yinxian Yang and 12 more · 2023

Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at the early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, the ROS-sens…

Nature Communications324 citationsDOI

Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs

Yifan Liu, Yushan Liang, Jing Yuhong, Peng Xin and 7 more · 2024

This manuscript offers a comprehensive overview of nanotechnology's impact on the solubility and bioavailability of poorly soluble drugs, with a focus on BCS Class II and IV drugs. We explore various nanoscale drug delivery systems (NDDSs), including lipid-based, polymer-based, nanoemulsions, nanogels, and inorganic carriers. These systems offer improved drug efficacy, targeting, and reduced side effects. Emphasizing the crucial role of nanoparticle size and surface modifications, the review discusses the advancements in NDDSs for enhanced therapeutic outcomes. Challenges such as production co…

Drug Design Development and Therapy322 citationsDOI

Ocular Drug Delivery: a Comprehensive Review

Sadek Ahmed, Maha M. Amin, Sinar Sayed · 2023

The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration is an interest of scientists for many decades. Their difficult mission is to prolong drug residence time and guarantee an appropriate ocular permeation. Several ocular obstacles oppose effective drug delivery such as precorneal, corneal, and blood-corneal barriers. Routes for ocular delivery include topical, intravitreal, intraocular, juxtascleral, subconjunctival, intracameral, and retrobulbar. More than 95% of market…

AAPS PharmSciTech319 citationsDOI

Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges

Mohammed Elmowafy, Khaled Shalaby, Mohammed H. Elkomy, Omar Awad Alsaidan and 3 more · 2023

In the last few decades, several natural bioactive agents have been widely utilized in the treatment and prevention of many diseases owing to their unique and versatile therapeutic effects, including antioxidant, anti-inflammatory, anticancer, and neuroprotective action. However, their poor aqueous solubility, poor bioavailability, low GIT stability, extensive metabolism as well as short duration of action are the most shortfalls hampering their biomedical/pharmaceutical applications. Different drug delivery platforms have developed in this regard, and a captivating tool of this has been the f…

Polymers317 citationsDOI

Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives

Haijie Han, Su Li, Mingyu Xu, Yueyang Zhong and 6 more · 2023

Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains a huge challenge due to multiple ocular barriers that significantly affect the ultimate therapeutic efficacy of drugs. Recent advances in nanocarrier technology offer a promising opportunity to overcome these barriers by providing enhanced penetration, increased retention, improved solubility, reduced toxicity, prolonged release, and targeted delivery of the loaded drug to…

Advanced Drug Delivery Reviews312 citationsDOI

Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs

Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia and 6 more · 2023

The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple benefits. Their small droplet size, which is generally between 20 and 200 nanometers, creates a significant interfacial area for drug dissolution, improving the solubility and bioavailability of drugs that are weakly water-soluble. Additionally, nanoemulsions are a flexible platform for drug administration across various therapeutic areas since they can encapsulate h…

Scientifica306 citationsDOI

The REporting of A Disproportionality Analysis for DrUg Safety Signal Detection Using Individual Case Safety Reports in PharmacoVigilance (READUS-PV): Explanation and Elaboration

Michele Fusaroli, Francesco Salvo, Bernard Bégaud, Thamir M. Alshammari and 30 more · 2024

In pharmacovigilance, disproportionality analyses based on individual case safety reports are widely used to detect safety signals. Unfortunately, publishing disproportionality analyses lacks specific guidelines, often leading to incomplete and ambiguous reporting, and carries the risk of incorrect conclusions when data are not placed in the correct context. The REporting of A Disproportionality analysis for drUg Safety signal detection using individual case safety reports in PharmacoVigilance (READUS-PV) statement was developed to address this issue by promoting transparent and comprehensive…

Drug Safety301 citationsDOI

Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

Shang Lyu, Zhifei Dong, Xiaoxiao Xu, Ho‐Pan Bei and 5 more · 2023

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Although microneedles are initially designed to penetrate stratum corneum of skin for transdermal drug delivery, they, recently, have been used to promote wound healing and regeneration of diverse tissues and organs and the results are promising. Despite there are reviews about microneedles, few of them focus on wound healing and tissue regeneration. Here, we review the recent advances o…

Bioactive Materials256 citationsDOI

“Magic Chloro”: Profound Effects of the Chlorine Atom in Drug Discovery

Debora Chiodi, Yoshihiro Ishihara · 2023

Chlorine is one of the most common atoms present in small-molecule drugs beyond carbon, hydrogen, nitrogen, and oxygen. There are currently more than 250 FDA-approved chlorine-containing drugs, yet the beneficial effect of the chloro substituent has not yet been reviewed. The seemingly simple substitution of a hydrogen atom (R = H) with a chlorine atom (R = Cl) can result in remarkable improvements in potency of up to 100,000-fold and can lead to profound effects on pharmacokinetic parameters including clearance, half-life, and drug exposure in vivo. Following the literature terminology of the…

Journal of Medicinal Chemistry254 citationsDOI

Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury

Hartmut Jaeschke, Anup Ramachandran · 2024

Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western countries, and, because of translational relevance of animal models, APAP is mechanistically the most studied drug. This review covers intracellular signaling events starting with drug metabolism and the central role of mitochondrial dysfunction involving oxidant stress and peroxynitrite. Mitochondria-derived endonucleases trigger nuclear DNA fragmentation, the point of no return for cell death. In addition, adaptive mechanisms that limit cell death are discussed including autophagy, mitochondrial morp…

Annual Review of Pathology Mechanisms of Disease232 citationsDOI

Bioinspired Adaptable Indwelling Microneedles for Treatment of Diabetic Ulcers

Xiaoxuan Zhang, Jingjing Gan, Lu Fan, Zhiqiang Luo and 1 more · 2023

Microneedles provide an effective strategy for transdermal drug delivery. Many endeavors have been devoted to developing smart microneedles that can respond to and interact with pathophysiological environments. Here, novel bioinspired adaptable indwelling microneedles with therapeutic exosome encapsulation are presented for diabetic wound healing by a combined fabrication strategy of template replication and 3D transfer printing. Such microneedles are composed of mesenchymal stem cell (MSC)-exosomes-encapsulated adjustable poly(vinyl alcohol) (PVA) hydrogel needle tips and detachable 3M medica…

Advanced Materials227 citationsDOI

Novel nano-drug delivery system for natural products and their application

Li Huang, Xuehua Huang, Xi Yang, Jia-Qin Hu and 3 more · 2024

The development of natural products for potential new drugs faces obstacles such as unknown mechanisms, poor solubility, and limited bioavailability, which limit the broadened applicability of natural products. Therefore, there is a need for advanced pharmaceutical formulations of active compounds or natural products. In recent years, novel nano-drug delivery systems (NDDS) for natural products, including nanosuspensions, nanoliposomes, micelle, microemulsions/self-microemulsions, nanocapsules, and solid lipid nanoparticles, have been developed to improve solubility, bioavailability, and tissu…

Pharmacological Research222 citationsDOI

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

Lakshmi Kumari, Yash Choudhari, Preeti Patel, Ghanshyam Das Gupta and 4 more · 2023

A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70-90% of drug candidates in the development stage are poorly soluble, which results in low bioavailability, diminished therapeutic effects, and dosage escalation. Because of this, solubility must be taken into consideration when developing and fabricating pharmaceutical products. To date, a number of approaches have been investigated to address the proble…

Life219 citationsDOI

A Review on Role of Guava on Diabetes Patients

A. Gayathri, P Dhanushya · 2024

Diabetes mellitus (DM) is a disease that causes abnormal blood glucose levels. This is a globally prevalent metabolic disorder. Diabetes is the fourth biggest cause of death, as reported by the international diabetes federation. The use of herbal products has significantly risen globally in the modern era. Guava, also known as Psidiumguajava L., is a vital tropical food plant with a range of therapeutic uses. It is extensively utilized as a treatment for various illnesses and is easily accessible around the world, particularly in Asian nations. Psidiumguajava contains bioactive constituents in…

International Journal of Innovative Science and Research Technology (IJISRT)214 citationsDOI

Recent Applications of PLGA in Drug Delivery Systems

Jie Yang, Huiying Zeng, Yusheng Luo, Ying Chen and 3 more · 2024

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, and end caps, that significantly influence drug release profiles and degradation times. This review also covers the extensive literature on the application of PLGA in delivering small-molecule drugs, proteins, peptides, antibiotics, and antiviral drugs. Furthermore, we discuss the role of PLGA-based DDSs in the…

Polymers213 citationsDOI

Polymer-based biomaterials for pharmaceutical and biomedical applications: A focus on topical drug administration

Patrícia C. Pires, Filipa Mascarenhas‐Melo, Kelly Pedrosa, Daniela Lopes and 6 more · 2023

The increasing emergence of skin diseases and the difficulty in treating damaged skin using conventional therapies have been calling for the development of novel drug delivery systems towards an effective topical drug administration. Drug delivery systems are able to produce these results by means of improved drug delivery features, including controlled drug release, increased drug skin permeation and retention, and decreased systemic adverse effects. Natural polymers have proved to be good excipients for incorporation in hybrid systems (nanocarriers dispersed in a semisolid base) for the mana…

European Polymer Journal210 citationsDOI

The Reporting of a Disproportionality Analysis for Drug Safety Signal Detection Using Individual Case Safety Reports in PharmacoVigilance (READUS-PV): Development and Statement

Michele Fusaroli, Francesco Salvo, Bernard Bégaud, Thamir M. Alshammari and 30 more · 2024

BACKGROUND AND AIM: Disproportionality analyses using reports of suspected adverse drug reactions are the most commonly used quantitative methods for detecting safety signals in pharmacovigilance. However, their methods and results are generally poorly reported in published articles and existing guidelines do not capture the specific features of disproportionality analyses. We here describe the development of a guideline (REporting of A Disproportionality analysis for drUg Safety signal detection using individual case safety reports in PharmacoVigilance [READUS-PV]) for reporting the results o…

Drug Safety208 citationsDOI

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

Neha Raina, Radha Rani, Vijay Kumar Thakur, Madhu Gupta · 2023

Skin, the largest organ in humans, is an efficient route for the delivery of drugs as it circumvents several disadvantages of the oral and parenteral routes. These advantages of skin have fascinated researchers in recent decades. Drug delivery via a topical route includes moving the drug from a topical product to a locally targeted region with dermal circulation throughout the body and deeper tissues. Still, due to the skin's barrier function, delivery through the skin can be difficult. Drug delivery to the skin using conventional formulations with micronized active components, for instance, l…

ACS Omega203 citationsDOI

Single-cell multi-omics in the medicinal plant Catharanthus roseus

Chenxin Li, Joshua C. Wood, Anh Hai Vu, John P. Hamilton and 9 more · 2023

Advances in omics technologies now permit the generation of highly contiguous genome assemblies, detection of transcripts and metabolites at the level of single cells and high-resolution determination of gene regulatory features. Here, using a complementary, multi-omics approach, we interrogated the monoterpene indole alkaloid (MIA) biosynthetic pathway in Catharanthus roseus, a source of leading anticancer drugs. We identified clusters of genes involved in MIA biosynthesis on the eight C. roseus chromosomes and extensive gene duplication of MIA pathway genes. Clustering was not limited to the…

Nature Chemical Biology201 citationsDOI

Drug-induced liver injury: a comprehensive review

Tom Hosack, Djamil Damry, Sujata Biswas · 2023

Drug-induced liver injury (DILI) remains a challenge in clinical practice and is still a diagnosis of exclusion. Although it has a low incidence amongst the general population, DILI accounts for most cases of acute liver failure with a fatality rate of up to 50%. While multiple mechanisms of DILI have been postulated, there is no clear causal relationship between drugs, risk factors and mechanisms of DILI. Current best practice relies on a combination of high clinical suspicion, thorough clinical history of risk factors and timeline, and extensive hepatological investigations as supported by t…

Therapeutic Advances in Gastroenterology196 citationsDOI

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease

Annabelle S. Chidiac, Nicholas A. Buckley, Firouzeh Noghrehchi, Rose Cairns · 2023

INTRODUCTION: Paracetamol is one of the most used medicines worldwide and is the most common important poisoning in high-income countries. In overdose, paracetamol causes dose-dependent hepatotoxicity. Acetylcysteine is an effective antidote, however despite its use hepatotoxicity and many deaths still occur. AREAS COVERED: This review summarizes paracetamol overdose and toxicity (including mechanisms, risk factors, risk assessment, and treatment). In addition, we summarize the epidemiology of paracetamol overdose worldwide. A literature search on PubMed for poisoning epidemiology and mortalit…

Expert Opinion on Drug Metabolism & Toxicology196 citationsDOI

BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins

Xiangren Kong, Chao Liu, Zuzhen Zhang, Meiqi Cheng and 16 more · 2023

Traditional Chinese medicine (TCM) is increasingly recognized and utilized worldwide. However, the complex ingredients of TCM and their interactions with the human body make elucidating molecular mechanisms challenging, which greatly hinders the modernization of TCM. In 2016, we developed BATMAN-TCM 1.0, which is an integrated database of TCM ingredient-target protein interaction (TTI) for pharmacology research. Here, to address the growing need for a higher coverage TTI dataset, and using omics data to screen active TCM ingredients or herbs for complex disease treatment, we updated BATMAN-TCM…

Nucleic Acids Research196 citationsDOI

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Nakamwi Akombaetwa, Ange B. Ilangala, Lorraine Thom, Patrick B. Memvanga and 2 more · 2023

Skin delivery is an exciting and challenging field. It is a promising approach for effective drug delivery due to its ease of administration, ease of handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, and many other advantages. The main associated challenge, however, is low skin permeability. The skin is a healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in skin delivery (both topical and transdermal) depend on overcoming the challenges associated with drug molecule permeation and skin irritatio…

Pharmaceutics195 citationsDOI

Recent Advancement of Medical Patch for Transdermal Drug Delivery

Won Fen Wong, Kuan Ping Ang, Gautam Sethi, Chung Yeng Looi · 2023

Transdermal patches are a non-invasive method of drug administration. It is an adhesive patch designed to deliver a specific dose of medication through the skin and into the bloodstream throughout the body. Transdermal drug delivery has several advantages over other routes of administration, for instance, it is less invasive, patient-friendly, and has the ability to bypass first-pass metabolism and the destructive acidic environment of the stomach that occurs upon the oral ingestion of drugs. For decades, transdermal patches have attracted attention and were used to deliver drugs such as nicot…

Medicina194 citationsDOI

Microneedle system for tissue engineering and regenerative medicine

Yixin Zhang, Yanteng Xu, Huimin Kong, Jiabin Zhang and 5 more · 2023

Global increasing demand for high life quality and length facilitates the development of tissue engineering and regenerative medicine, which apply multidisciplinary theories and techniques to achieve the structural reconstruction and functional recovery of disordered or damaged tissues and organs. However, the clinical performances of adopted drugs, materials, and powerful cells in the laboratory are inescapably limited by the currently available technologies. To tackle the problems, versatile microneedles are developed as the new platform for local delivery of diverse cargos with minimal inva…

Exploration193 citationsDOI

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins

Clément G. Yedjou, Jameka Grigsby, Ariane Mbemi, Daryllynn Nelson and 3 more · 2023

Diabetes mellitus (DM) is a serious chronic metabolic disease that is associated with hyperglycemia and several complications including cardiovascular disease and chronic kidney disease. DM is caused by high levels of blood sugar in the body associated with the disruption of insulin metabolism and homeostasis. Over time, DM can induce life-threatening health problems such as blindness, heart disease, kidney damage, and stroke. Although the cure of DM has improved over the past decades, its morbidity and mortality rates remain high. Hence, new therapeutic strategies are needed to overcome the b…

International Journal of Molecular Sciences192 citationsDOI

Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment

Yiming Xiang, Jiali Lu, Congyang Mao, Yizhou Zhu and 7 more · 2023

Acne is an inflammatory skin disease mainly caused by Propionibacterium acnes , which can cause local inflammatory reactions and develop into chronic inflammatory diseases in severe cases. To avoid the use of antibiotics and to effectively treat the site of acne, we report a sodium hyaluronate microneedle patch that mediates the transdermal delivery of ultrasound-responsive nanoparticles for the effective treatment of acne. The patch contains nanoparticles formed by zinc porphyrin–based metal-organic framework and zinc oxide (ZnTCPP@ZnO). We demonstrated activated oxygen-mediated killing of P.…

Science Advances189 citationsDOI